DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zfp35 and CG11247

DIOPT Version :9

Sequence 1:	NP_035885.2	Gene:	Zfp35 / 22694	MGIID:	99179	Length:	580	Species:	Mus musculus
Sequence 2:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	401	Identity:	129/401 - (32%)
Similarity:	192/401 - (47%)	Gaps:	32/401 - (7%)

- Green bases have known domain annotations that are detailed below.

Mouse    27 PATEEEMTGKIGTVTEESGSLEE------DVPHDSRGKEFREFGEELNDQML--------FRRRQ 77
            ||..|...|....:.....||..      |...|..|::..:..:.:..|:.        .:|:.
  Fly    28 PAARESSPGPTLAIKRRKSSLASLRDACVDEEEDDGGEQDSKDDDYVQPQLKKSARKGEPVKRKH 92

Mouse    78 YNCDECDQSFAWSTGLIRHQRTH--WKPYECEECGKAFRMSSALVLH-QRIHTGEKPYPCSWCIK 139
            :.|.:|.:.|...|.|.||...|  .:|::|::|||::|.:..|..| ...|...|.:.||.|.|
  Fly    93 HVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPK 157

Mouse   140 SFSRSSDLIKHQRVHTGEKPYKCDECGKAFSQSSDLMIHQRIH--TGEKPYQCSHCSKSFSQHSG 202
            ||:....|..|.|:|:|||||.||.|.|.|::...|..|...|  |..:.:.|:.||.|||.::.
  Fly   158 SFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNAN 222

Mouse   203 MVKHLRIHTGEKPYMCNHCYKHFSQSSDLIKHQRIHTGEKPYK-----CDVCGKAFSQSSDRILH 262
            :..|:..|.....:.|:.|...|:....|    |.|..::.:|     |::|.|......|...|
  Fly   223 LRVHMERHEQGMEHRCSICENQFANELAL----RAHINQEHHKLTQFECEICHKMIEPDEDLATH 283

Mouse   263 QRIHTGEKPYPCAQCNKSFSQNSDLIKHRRIHTGEKPYKCSECGKAFNQSSVLILHQRIHTGEKP 327
            .:.||..|.:.|..||..|:|.|....|.|:||||:||:|..|.:.|..||||.||.|.||||||
  Fly   284 MQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKP 348

Mouse   328 YPCNQCTK--SFSRLSDLINH-QRIHTGEKPYPCSQCSKMFSRRSDLVKHYRIHTGEKPYECDKC 389
            :.|..|..  :||:|:.|.|| ::||..:|||.|..|...|..:.:|..|.. |..:.|.:.||.
  Fly   349 FRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVE-HCAKCPVDGDKP 412

Mouse   390 GKTFSQSSNLI 400
            ....|:.:.::
  Fly   413 SGNQSEDAQIL 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zfp35	NP_035885.2	C2H2 Zn finger	80..100	CDD:275368	7/19 (37%)
		COG5048	102..489	CDD:227381	110/310 (35%)
		C2H2 Zn finger	106..126	CDD:275368	7/20 (35%)
		C2H2 Zn finger	134..154	CDD:275368	9/19 (47%)
		C2H2 Zn finger	162..182	CDD:275368	7/19 (37%)
		C2H2 Zn finger	190..210	CDD:275368	7/19 (37%)
		C2H2 Zn finger	218..238	CDD:275368	5/19 (26%)
		C2H2 Zn finger	246..266	CDD:275368	5/19 (26%)
		C2H2 Zn finger	274..294	CDD:275368	8/19 (42%)
		C2H2 Zn finger	302..322	CDD:275368	10/19 (53%)
		C2H2 Zn finger	330..350	CDD:275368	8/22 (36%)
		C2H2 Zn finger	358..378	CDD:275368	5/19 (26%)
		C2H2 Zn finger	386..406	CDD:275368	3/15 (20%)
		C2H2 Zn finger	414..434	CDD:275368
		C2H2 Zn finger	442..462	CDD:275368
		C2H2 Zn finger	470..490	CDD:275368
		C2H2 Zn finger	498..518	CDD:275368
		C2H2 Zn finger	526..545	CDD:275368
		zf-H2C2_2	541..562	CDD:404364
		C2H2 Zn finger	553..573	CDD:275368
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	54/158 (34%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	9/24 (38%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	9/19 (47%)
		zf-H2C2_2	165..189	CDD:290200	14/23 (61%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	63/180 (35%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	6/25 (24%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	8/19 (42%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	10/19 (53%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	4/16 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000