Protein Alignment FGR and BEM1

DIOPT Version :9

• Sequence 1: NP_001036194.1
• Gene: FGR / 2268
• HGNCID: 3697
• Length: 529
• Species: Homo sapiens
• Sequence 2: NP_009759.3
• Gene: BEM1 / 852499
• SGDID: S000000404
• Length: 551
• Species: Saccharomyces cerevisiae
• Alignment Length: 532
• Identity: 96/532 - (18%)
• Similarity: 174/532 - (32%)
• Gaps: 192/532 - (36%)

Human    14 TAKEDAGLEGDFRSYGAAD----HYGPDPT----------------KARPASSFAHIPNYSNFSS 58
            |:||.:.:||:| .|.:.|    :...:|:                :.:|:|     .|.||.||
Yeast    87 TSKELSFMEGEF-FYVSGDEKDWYKASNPSTGKEGVVPKTYFEVFDRTKPSS-----VNGSNSSS 145

Human    59 QAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSS- 122
            :.:....|:.|::..         |.|||::|...|:||...||...|..:...:|:.|:.:..
Yeast   146 RKVTNDSLNMGSLYA---------IVLYDFKAEKADELTTYVGENLFICAHHNCEWFIAKPIGRL 201

Human   123 GKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDW 187
            |..|.:|..:|:.:|                     ::.|...|..:|   |..|.....::::|
Yeast   202 GGPGLVPVGFVSIID---------------------IATGYATGNDVI---EDIKSVNLPTVQEW 242

Human   188 DQTRGDHVKHYKIRKLDMGG-----------------------------------------YYIT 211
            .    .::..||...:.:|.                                         :.:.
Yeast   243 K----SNIARYKASNISLGSVEQQQQQSITKPQNKSAKLVDGELLVKASVESFGLEDEKYWFLVC 303

Human   212 TRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGD 276
            ..:.....::|.::|.:..|....||.|     .|...|..:||.
Yeast   304 CELSNGKTRQLKRYYQDFYDLQVQLLDA-----FPAEAGKLRDAG-------------------- 343

Human   277 VWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGS 341
               |.|:       |.:.|....|..::..:...|  |.:.|....|.:...|.||....|.|..
Yeast   344 ---GQWS-------KRIMPYIPGPVPYVTNSITKK--RKEDLNIYVADLVNLPDYISRSEMVHSL 396

Human   342 LL--------DFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNY--IHRDLRAANILVGE--RL 394
            .:        :|.::....:::..|..|.|......    :..|:  .::|    |.|.||  :|
Yeast   397 FVVLNNGFDREFERDENQNNIKTLQENDTATFATAS----QTSNFASTNQD----NTLTGEDLKL 453

Human   395 ACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFG------RFTIKSDVWSFGILLTELIT 453
            ..|::|..|:            |||     .||..:..|      :|..|.|:::       |:.
Yeast   454 NKKLSDLSLS------------GSK-----QAPAQSTSGLKTTKIKFYYKDDIFA-------LML 494

Human   454 KGRIPYPGMNKR 465
            ||...|..:..:
Yeast   495 KGDTTYKELRSK 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGR	NP_001036194.1	SH3	80..137	CDD:327375	17/57 (30%)
		SH2_Src_Fgr	140..240	CDD:198230	14/140 (10%)
		PKc_like	267..514	CDD:328722	41/217 (19%)
BEM1	NP_009759.3	SH3_Bem1p_1	76..127	CDD:212811	9/40 (23%)
		SH3_Bem1p_2	159..214	CDD:212812	17/63 (27%)
		PX_Bem1p	284..400	CDD:132800	24/152 (16%)
		PB1	478..549	CDD:214770	7/36 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I3374
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000