DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FGR and SLA1

DIOPT Version :9

Sequence 1:	NP_001036194.1	Gene:	FGR / 2268	HGNCID:	3697	Length:	529	Species:	Homo sapiens
Sequence 2:	NP_009546.1	Gene:	SLA1 / 852276	SGDID:	S000000103	Length:	1244	Species:	Saccharomyces cerevisiae

Alignment Length:	116	Identity:	35/116 - (30%)
Similarity:	58/116 - (50%)	Gaps:	12/116 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    83 IALYDYEARTEDDLTFTKGEKFHILNNTEG-DWWEARSLSSGKTGCIPSNYVAPV-DSIQAEEWY 145
            |..||:.|.::|:||...|:|.:||::.:. |||..:.:.|||:|.:|:.::.|| |....|...
Yeast   359 IVQYDFMAESQDELTIKSGDKVYILDDKKSKDWWMCQLVDSGKSGLVPAQFIEPVRDKKHTESTA 423

Human   146 FGKIGRKDAERQLL-SPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHV 195
            .|.|  |..::... ||...      |....:|...:.|.:| |:.:.|.|
Yeast   424 SGII--KSIKKNFTKSPSRS------RSRSRSKSNANASWKD-DELQNDVV 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FGR	NP_001036194.1	SH3	80..137	CDD:327375	21/55 (38%)
		SH2_Src_Fgr	140..240	CDD:198230	13/57 (23%)
		PKc_like	267..514	CDD:328722
SLA1	NP_009546.1	SH3_Sla1p_1	7..64	CDD:212707
		SH3	73..127	CDD:327375
		SH3_Sla1p_3	356..412	CDD:212709	19/52 (37%)
		SHD1	489..554	CDD:309199
		SAM_SLA1_fungal	655..716	CDD:188931
		MotB_plug	<738..848	CDD:330912
		Med15	831..>1201	CDD:312941
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I3374
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000