DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FGR and Fgr

DIOPT Version :9

Sequence 1:	NP_001036194.1	Gene:	FGR / 2268	HGNCID:	3697	Length:	529	Species:	Homo sapiens
Sequence 2:	NP_077059.2	Gene:	Fgr / 79113	RGDID:	621319	Length:	517	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	450/529 - (85%)
Similarity:	473/529 - (89%)	Gaps:	12/529 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQAINPGF 65
            |||||||||||  ..|||.||||||||.||.:.|.||||:.|.          |:.|.|.|:|.|
  Rat     1 MGCVFCKKLEP--APKEDVGLEGDFRSQGAEERYYPDPTQGRS----------SSISPQPISPAF 53

Human    66 LDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPS 130
            |:.|.||.|||.|||:|:|||||||||.||||||||||||||||||.|||||||||||:||.:||
  Rat    54 LNVGNIRSVSGTGVTIFVALYDYEARTGDDLTFTKGEKFHILNNTEYDWWEARSLSSGRTGYVPS 118

Human   131 NYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHV 195
            |||||||||||||||||||.||||||||||.||||||||||||||||||||||||||||.||||:
  Rat   119 NYVAPVDSIQAEEWYFGKISRKDAERQLLSDGNPQGAFLIRESETTKGAYSLSIRDWDQNRGDHI 183

Human   196 KHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISR 260
            ||||||||||||||||||.||.|||:||:||||||||||.||.|||.:|||||||||||||||.|
  Rat   184 KHYKIRKLDMGGYYITTRAQFESVQDLVRHYMEVNDGLCYLLTAPCMVMKPQTLGLAKDAWEIDR 248

Human   261 SSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVV 325
            :||.|:|||||||||||||||||.||||||||||||||||||||||||:||||||||||||||||
  Rat   249 NSIALDRRLGTGCFGDVWLGTWNCSTKVAVKTLKPGTMSPKAFLEEAQIMKLLRHDKLVQLYAVV 313

Human   326 SEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILV 390
            |||||||||||||:||||||||:.:|.:|.||.||||||||||||||||||||||||||||||||
  Rat   314 SEEPIYIVTEFMCYGSLLDFLKDRKGHNLMLPNLVDMAAQVAEGMAYMERMNYIHRDLRAANILV 378

Human   391 GERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKG 455
            ||.|.||||||||||||.||||||.||:||||||||||||||||||:||||||||||||||||||
  Rat   379 GEHLICKIADFGLARLIVDDEYNPQQGTKFPIKWTAPEAALFGRFTVKSDVWSFGILLTELITKG 443

Human   456 RIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAE 520
            |:||||||.||||||||.|||||||||||.||||.||||||||||||||||||||||||||||.|
  Rat   444 RVPYPGMNNREVLEQVEHGYHMPCPPGCPVSLYEVMEQTWRLDPEERPTFEYLQSFLEDYFTSTE 508

Human   521 PQYQPGDQT 529
            |||||||||
  Rat   509 PQYQPGDQT 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FGR	NP_001036194.1	SH3	80..137	CDD:327375	49/56 (88%)
		SH2_Src_Fgr	140..240	CDD:198230	89/99 (90%)
		PKc_like	267..514	CDD:328722	225/246 (91%)
Fgr	NP_077059.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	17..46		17/38 (45%)
		SH3	68..125	CDD:418401	49/56 (88%)
		SH2_Src_Fgr	128..228	CDD:198230	89/99 (90%)
		PKc_like	255..502	CDD:419665	225/246 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83684054
Domainoid	1	1.000	471	1.000	Domainoid score	I8238
eggNOG	1	0.900	-	-		E2759_KOG0197
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3842
Inparanoid	1	1.050	925	1.000	Inparanoid score	I6123
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG52589
OrthoDB	1	1.010	-	-		D101062at32523
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		oto138259
orthoMCL	1	0.900	-	-		OOG6_100661
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1168
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270