DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FGR and Src64B

DIOPT Version :9

Sequence 1:	NP_001036194.1	Gene:	FGR / 2268	HGNCID:	3697	Length:	529	Species:	Homo sapiens
Sequence 2:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	245/519 - (47%)
Similarity:	334/519 - (64%)	Gaps:	28/519 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    20 GLEGDFRSYGAA--DHYGPDPTKARPASSFAHIPNYSNFSSQAINPGFLD----SGTIRGVSGIG 78
            |:.|...:.|.:  ..|.|||....|.              :....|.:|    ..|..||.|:.
  Fly    45 GVLGQKHNNGGSLDSRYTPDPNHRGPL--------------KIGGKGGVDIIRPRTTPTGVPGVV 95

Human    79 V-TLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142
            : .:.:|||||::|.|.||:|.||::..::::||.|||...:|::.:.|.||.|:||...|:.:|
  Fly    96 LKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSE 160

Human   143 EWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGG 207
            :|:|..:.||:|::.||:..||:|.||:|.||.....||||::||:..||.|||||:|:.||.||
  Fly   161 DWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGG 225

Human   208 YYITTRVQFNSVQELVQHYMEVND-GLCNLLIAPCTIMKPQTLGLA---KDAWEISRSSITLERR 268
            |||.|...|.|:|.||..|.:.|. |||::|..||...:||...|.   :|.:||.||.|.|.|:
  Fly   226 YYIATNQTFPSLQALVMAYSKENALGLCHILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQLLRK 290

Human   269 LGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-EEPIYI 332
            ||.|.||:|:.|.|..|..||||||:.||||..|||:||.:||..||::||.||||.| ||||||
  Fly   291 LGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYI 355

Human   333 VTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACK 397
            |.|:|..|||||||:..:|:.|....|:.:|.|||.||.|:|....|||||.|.|:|:||....|
  Fly   356 VQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAK 420

Human   398 IADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGM 462
            |.||||||:|.||||.|.|||:||:|||||||.::|:|:|||||||:||||.||.|.|::|||||
  Fly   421 ICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGM 485

Human   463 NKREVLEQVEQGYHMPCPPG--CPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQ 524
            :.|||:|.:|:|:.||.|..  .|.::|:.:.|.|...||:|||||:|..:.|.:..::|..|:
  Fly   486 HSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPYR 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FGR	NP_001036194.1	SH3	80..137	CDD:327375	24/56 (43%)
		SH2_Src_Fgr	140..240	CDD:198230	49/100 (49%)
		PKc_like	267..514	CDD:328722	142/249 (57%)
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	21/50 (42%)
		SH2_Src_family	158..259	CDD:199827	49/100 (49%)
		STYKc	285..537	CDD:214568	144/251 (57%)
		PTKc_Src_like	289..538	CDD:270630	142/248 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I6763
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100661
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.780