DRSC/TRiP Functional Genomics Resources

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Protein Alignment FGR and Abl

DIOPT Version :10

Sequence 1:NP_005239.1 Gene:FGR / 2268 HGNCID:3697 Length:529 Species:Homo sapiens
Sequence 2:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster


Alignment Length:445 Identity:205/445 - (46%)
Similarity:282/445 - (63%) Gaps:18/445 - (4%)


- Green bases have known domain annotations that are detailed below.


Human    81 LFIALYDYEARTEDDLTFTKGEKFHILN-NTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEW 144
            ||:||||::|..|:.|:..|||:..||: |..|:|.||.| .||..|.:|||||.|::|::...|
  Fly   209 LFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHS-DSGNVGWVPSNYVTPLNSLEKHSW 272

Human   145 YFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYY 209
            |.|.|.|..|| .|||.| ..|:||:||||::.|..|:|:|     ....|.||:|.:...|..:
  Fly   273 YHGPISRNAAE-YLLSSG-INGSFLVRESESSPGQRSISLR-----YEGRVYHYRISEDPDGKVF 330

Human   210 ITTRVQFNSVQELVQHYMEVND--GLCNLLIAPCTIM-KPQTLGLA--KDAWEISRSSITLERRL 269
            :|...:||::.|||.|:...::  ||...|:.|.... ||....|:  .|.|||.|:.|.::.:|
  Fly   331 VTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPDEWEICRTDIMMKHKL 395

Human   270 GTGCFGDVWLGTWN--GSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEE-PIY 331
            |.|.:|:|:...|.  |:| |||||||..||:.|.|||||.:||.::|..||||..|.:.| |.|
  Fly   396 GGGQYGEVYEAVWKRYGNT-VAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFY 459

Human   332 IVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLAC 396
            |:||||.||:|||||::...:.|....|:.||.|:|.||:|:|..|||||||.|.|.|||:....
  Fly   460 IITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLV 524

Human   397 KIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPG 461
            |:||||||||::||.|....|:||||||||||...:.:|:.|||||:||:||.|:.|.|..|||.
  Fly   525 KVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPA 589

Human   462 MNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516
            ::..:|..::::||.|..|||||..:|:.|.|.|:.|..:||||:.:...||..|
  Fly   590 IDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMF 644

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FGRNP_005239.1 SH3 80..137 CDD:473055 29/56 (52%)
SH2_Src_Fgr 140..240 CDD:198230 37/101 (37%)
Protein Kinases, catalytic domain 267..514 CDD:473864 126/249 (51%)
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 28/54 (52%)
SH2_ABL 268..363 CDD:198189 37/101 (37%)
PTKc_Abl 382..644 CDD:270645 132/262 (50%)
FABD 1584..1723 CDD:197885
Blue background indicates that the domain is not in the aligned region.

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