Protein Alignment FGR and Ret

DIOPT Version :10

• Sequence 1: NP_005239.1
• Gene: FGR / 2268
• HGNCID: 3697
• Length: 529
• Species: Homo sapiens
• Sequence 2: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Alignment Length: 287
• Identity: 104/287 - (36%)
• Similarity: 153/287 - (53%)
• Gaps: 26/287 - (9%)

Human   250 GLAKDAWEISRSSITLERRLGTGCFGDVWLGTWN------GSTKVAVKTLKPGTMSPK--AFLEE 306
            |.||  ||..|..:.|:..||.|.||.|..|...      |.|.||||.||.|:.|.:  |.|.|
  Fly   760 GDAK--WEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSE 822

Human   307 AQVMKLLRHDKLVQLYAVV--SEEPIYIVTEFMCHGSLLDFLK-----NPEGQD-------LRLP 357
            .|:::.:.|..:::|....  ||.|:.|: |:..:|||..:|:     ...|.|       :.:.
  Fly   823 FQLLQEVSHPNVIKLLGACTSSEAPLLII-EYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVK 886

Human   358 QLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLAR-LIKDDEYNPCQGSKFP 421
            .::..|.|:.:||||:..:..:||||.|.|:|:.:...|||:||||.| :.:||.|......:.|
  Fly   887 MVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVP 951

Human   422 IKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPAS 486
            :||.|||:.....:|.||||||||:|..||||.|..||||:..:.:...::.||.|..|..|..:
  Fly   952 VKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEA 1016

Human   487 LYEAMEQTWRLDPEERPTFEYLQSFLE 513
            :|..:...|..:|..||:|::|.|..|
  Fly  1017 VYSIVRTCWADEPNGRPSFKFLASEFE 1043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGR	NP_005239.1	SH3	80..137	CDD:473055
		SH2_Src_Fgr	140..240	CDD:198230
		Protein Kinases, catalytic domain	267..514	CDD:473864	97/270 (36%)
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	98/275 (36%)