Protein Alignment FGR and Csk

DIOPT Version :10

• Sequence 1: NP_005239.1
• Gene: FGR / 2268
• HGNCID: 3697
• Length: 529
• Species: Homo sapiens
• Sequence 2: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Alignment Length: 501
• Identity: 178/501 - (35%)
• Similarity: 250/501 - (49%)
• Gaps: 74/501 - (14%)

Human    33 HYGPDPTKA-RPASSFAHIPNYSNFSSQAINPGFLDSGTIRGVSGIG-VTLFIALYDYEARTEDD 95
            |..|.|.:| :||:                         :.||||.| ..:..:|:.::.   :.
  Fly   599 HTAPQPPQASQPAA-------------------------VVGVSGSGSAGMSTSLHSFDI---NG 635

Human    96 LTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVD------------SIQAEEWYFGK 148
            :|...|.      |....|      |||.|..:....::|..            .:.|..|:.|.
  Fly   636 VTAGSGV------NASSAW------SSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGS 688

Human   149 IGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTR 213
            |.|.:|| .||.| ...|.||:|||....|.|:|.:  ..|::   |:||:::.|: ....|...
  Fly   689 ITRDEAE-HLLQP-REDGLFLVRESTNFPGDYTLCV--CFQSK---VEHYRVKYLE-NKLTIDDE 745

Human   214 VQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGL-AKD----AWEISRSSITLERRLGTGC 273
            ..|.::.:||.||....||||..||.....:..|...: :||    .|.|..:.:.|...:|.|.
  Fly   746 EYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGE 810

Human   274 FGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVV-SEEPIYIVTEFM 337
            ||||.||... :.|||||.||......| ||.||.||..|.||.||:...:| :.:.:|:|||:|
  Fly   811 FGDVMLGILR-NEKVAVKMLKDEGAVQK-FLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYM 873

Human   338 CHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFG 402
            ..|||:|:|::...|.:.....:..|...|.||.|:|....:||||.|.|:|:.|....|::|||
  Fly   874 SKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFG 938

Human   403 LARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREV 467
            |||   ::.||...| |.|||||||||...|||:.|||:|||||||.|:.:.||:|||.:...:|
  Fly   939 LAR---EECYNLDVG-KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADV 999

Human   468 LEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLE 513
            ::.||.||.|..|.|||..:||.|.|.|.|:|.:||||..|:..|:
  Fly  1000 VKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKLQ 1045

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGR	NP_005239.1	SH3	80..137	CDD:473055	10/56 (18%)
		SH2_Src_Fgr	140..240	CDD:198230	36/99 (36%)
		Protein Kinases, catalytic domain	267..514	CDD:473864	115/248 (46%)
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	36/104 (35%)
		PTKc_Csk_like	793..1047	CDD:270635	118/259 (46%)