Protein Alignment FGR and FER

DIOPT Version :10

• Sequence 1: NP_005239.1
• Gene: FGR / 2268
• HGNCID: 3697
• Length: 529
• Species: Homo sapiens
• Sequence 2: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Alignment Length: 539
• Identity: 165/539 - (30%)
• Similarity: 245/539 - (45%)
• Gaps: 91/539 - (16%)

Human     3 CVFCKKLEPVATAKEDAGLEGDFR----SYGAADHY--GPDPTKARPASSFAHIPNYSN--FSSQ 59
            |..|.|...:..:|.......:|.    :..|||..  ...|...:|......|..:.:  |.|.
  Fly   840 CKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKDHPFESS 904

Human    60 AINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGK 124
            :   |.||..:.|.:...        .:.|....||:...|...:
  Fly   905 S---GELDENSDRDIDND--------EEEEDSASDDVLSMKDHCY-------------------- 938

Human   125 TGCIPSNYVAPVD-----SIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSI 184
              |:|| ..|.:.     .:..|||:.|.:.|::..|.|    |..|.||:||:...:.:..:..
  Fly   939 --CVPS-LAASISLSTNRPLYEEEWFHGVLPREEVVRLL----NNDGDFLVRETIRNEESQIVLS 996

Human   185 RDWDQTRGDHVKHYKIRKLDMGGYYITTRVQ---FNSVQELVQH--YMEVNDGLCNLLIAPCTIM 244
            ..|:    .| ||:.::....|.:    |.:   |.|:|||:.|  :.|:          |.|:.
  Fly   997 VCWN----GH-KHFIVQTTGEGNF----RFEGPPFASIQELIMHQYHSEL----------PVTVK 1042

Human   245 KPQTL--GLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTK--VAVKTLK---PGTMSPKA 302
            ....|  .:.::.||:|...:.|..|:|.|.||||:..... |||  |||||.:   |.....|
  Fly  1043 SGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLK-STKLDVAVKTCRMTLPDEQKRK- 1105

Human   303 FLEEAQVMKLLRHDKLVQLYAV-VSEEPIYIVTEFMCHGSLLDFL-KNPEGQDLRLPQLVDMAAQ 365
            ||:|.:::|...|..:|:|..: |.::||.||.|.:..||||.:| ||..|...|  |.:.|...
  Fly  1106 FLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTR--QQMGMCRD 1168

Human   366 VAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSK-FPIKWTAPEA 429
            .|.||.|:|..|.|||||.|.|.||....:.||:|||::|  :::||....|.| .|:|||||||
  Fly  1169 AAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEA 1231

Human   430 ALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQT 494
            ..||::|...||||:|||:.|:.:||..||.||......|:::.||.||.|...|..:|..|.|.
  Fly  1232 LNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQC 1296

Human   495 WRLDPEERPTFEYLQSFLE 513
            |..|.|.||.|:.:.:.::
  Fly  1297 WAADAESRPHFDEIYNVVD 1315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGR	NP_005239.1	SH3	80..137	CDD:473055	8/56 (14%)
		SH2_Src_Fgr	140..240	CDD:198230	26/104 (25%)
		Protein Kinases, catalytic domain	267..514	CDD:473864	107/255 (42%)
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	26/108 (24%)
		PTKc_Fes_like	1067..1315	CDD:270637	107/253 (42%)