Protein Alignment FGR and Ack-like

DIOPT Version :10

• Sequence 1: NP_005239.1
• Gene: FGR / 2268
• HGNCID: 3697
• Length: 529
• Species: Homo sapiens
• Sequence 2: NP_001260935.1
• Gene: Ack-like / 36442
• FlyBaseID: FBgn0263998
• Length: 1495
• Species: Drosophila melanogaster
• Alignment Length: 297
• Identity: 107/297 - (36%)
• Similarity: 156/297 - (52%)
• Gaps: 27/297 - (9%)

Human   258 ISRSSITLERRLGTGCFGDVWLGTW-NGSTK--VAVKTLKPGTM--SPKAFLEEAQVMKLLRHDK 317
            |...||::.::||||.||.|..|.| ||:.:  ||:|.|....|  :|..||:||.:|..:.|:.
  Fly   128 IPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHEN 192

Human   318 LVQLYAVV-SEEPIYIVTEFMCHGSLLDFLKNP--EGQDLRLPQLVDMAAQVAEGMAYMERMNYI 379
            :|:||.|| :.:.:.:|||.....|||:.||:.  ....|.:|.|.:.|.|:..||.|:|:...|
  Fly   193 IVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLI 257

Human   380 HRDLRAANILVGERLACKIADFGLARL--IKDDEY--NPCQGSKFPIKWTAPEAALFGRFTIKSD 440
            ||||.|.||||..:...||:||||:|.  :..|.|  |.....|.||.|.|||...:.|||..||
  Fly   258 HRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASD 322

Human   441 VWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYH--MPCPPGCPASLYEAMEQTWRLDPEERP 503
            ||:||:.|.|:.:.|..|:..:...::||.::...:  :..|..||:..|..|.:.|:.|..:||
  Fly   323 VWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRP 387

Human   504 TFEYLQSFLED--------YFTSAEPQ-----YQPGD 527
            .|..:...|.|        .....||:     |:.||
  Fly   388 RFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGD 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGR	NP_005239.1	SH3	80..137	CDD:473055
		SH2_Src_Fgr	140..240	CDD:198230
		Protein Kinases, catalytic domain	267..514	CDD:473864	98/260 (38%)
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		PTKc_Ack_like	137..398	CDD:270636	98/260 (38%)
		SH3	400..454	CDD:214620	5/25 (20%)
		CRIB	486..525	CDD:238077