Protein Alignment FGR and tor

DIOPT Version :10

• Sequence 1: NP_005239.1
• Gene: FGR / 2268
• HGNCID: 3697
• Length: 529
• Species: Homo sapiens
• Sequence 2: NP_476762.1
• Gene: tor / 35717
• FlyBaseID: FBgn0003733
• Length: 923
• Species: Drosophila melanogaster
• Alignment Length: 645
• Identity: 146/645 - (22%)
• Similarity: 221/645 - (34%)
• Gaps: 244/645 - (37%)

Human    92 TEDDLTFTKGEKFH-------ILNNTEGD--WWEARSLSSGKTGCI---PSNYV-----APVDSI 139
            |.|:|.|.|  ::|       |:|..|.|  |     |......|:   |.||.     .|.:..
  Fly   243 TVDNLEFDK--QYHVGVRTVNIMNRLESDLQW-----LPIAVPSCLDWYPYNYTLCPPHKPENLT 300

Human   140 QAEEWYFGKIGRKDA--ERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRK 202
            ..::.|...|...:.  .|....|.|    :.:...:..||...|:. ..||.|    .|:.:.|
  Fly   301 VTQKQYLPNILALNITWARPRYLPDN----YTLHIFDLFKGGTELNY-TLDQNR----SHFYVPK 356

Human   203 LDMGGYYITTRVQFNS---------VQELVQHYMEVNDG----LCNLLIAP--CTIM-------- 244
            :.:.|.:....:...|         ..:.|...:.:::|    |...:|.|  |.:|
  Fly   357 ITVLGSHFEVHLVAQSAGGKNVSGLTLDKVHRGVLLSEGNMVKLVLFIIVPICCILMLCSLTFCR 421

Human   245 ----KPQTLGL-AKDA------------------------------WEISRSSITLERRLGTGCF 274
                :.|.|.: ||||                              .|:...|:.|:..||.|.|
  Fly   422 RNRSEVQALQMDAKDAKASEFHLSLMDSSGLLVTLSANESLEVMDELEVEPHSVLLQDVLGEGAF 486

Human   275 GDVWLGTWNGSTKVAVKTLK--PGTMSPKAFLEEAQVMKLL-RHDKLVQL--YAVVSEEPIYIVT 334
            |.|..|.:. ..:||||.||  |......||..|.|::|.: :|..:|.:  |:......:.::.
  Fly   487 GLVRRGVYK-KRQVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLI 550

Human   335 EFMCHGSLLDFL----------------------------------------------------- 346
            |:...|||.:||
  Fly   551 EYCSLGSLQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEE 615

Human   347 -------------------------------------------------------------KNPE 350
                                                                         |...
  Fly   616 ESESDQTHSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDS 680

Human   351 GQDL-------------------------RLP----QLVDMAAQVAEGMAYMERMNYIHRDLRAA 386
            .||.                         |:|    .|:|:|.|||.||.::.:...:||||.|.
  Fly   681 KQDFKSDNKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAAR 745

Human   387 NILVGERLACKIADFGLAR-LIKDDEYNPCQGS-KFPIKWTAPEAALFGRFTIKSDVWSFGILLT 449
            |:|:....:.|||||||:| :..::.|....|| |.||||.|.|:.....:|.:|||||||:||.
  Fly   746 NVLISVDRSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLY 810

Human   450 ELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQ 509
            |:.|.|.:|||.::..::|:.:.||:.|..|.||...::..||..|...|..||||..|:
  Fly   811 EITTLGGMPYPSVSPSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALK 870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGR	NP_005239.1	SH3	80..137	CDD:473055	17/61 (28%)
		SH2_Src_Fgr	140..240	CDD:198230	19/114 (17%)
		Protein Kinases, catalytic domain	267..514	CDD:473864	98/393 (25%)
tor	NP_476762.1	PTKc	479..873	CDD:270623	98/393 (25%)