Protein Alignment FGR and Btk

DIOPT Version :10

• Sequence 1: NP_005239.1
• Gene: FGR / 2268
• HGNCID: 3697
• Length: 529
• Species: Homo sapiens
• Sequence 2: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Alignment Length: 495
• Identity: 199/495 - (40%)
• Similarity: 284/495 - (57%)
• Gaps: 30/495 - (6%)

Human    38 PTKARPASS---FAHIPNYSNFSSQAINPGFLDSGTIRGVSGIG------------VTLFIALYD 87
            ||..:|.||   |...|...|.     |...||:....|:...|            |.|.:|||.
  Fly   293 PTSLQPQSSLTTFKQSPTLLNG-----NGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYP 352

Human    88 YEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAP--VDSIQAEEWYFGKIG 150
            ::|....||:..|..::.::::::..||:.:. :.|..|.||||||.|  :..::..|||.|.:.
  Fly   353 FKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKD-ALGNVGYIPSNYVKPKALLGLERYEWYVGDMS 416

Human   151 RKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQ 215
            |:.|| .||..|:.:|.|::|:| :|||.|:||:.  .:....|||||.|::.....||::.:..
  Fly   417 RQRAE-SLLKQGDKEGCFVVRKS-STKGLYTLSLH--TKVPQSHVKHYHIKQNARCEYYLSEKHC 477

Human   216 FNSVQELVQHYMEVNDGL-CNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWL 279
            ..::.:|:.::...:.|| |.|..:||....|.|.||:.|.|||....:.|...||:|.||.|..
  Fly   478 CETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRR 542

Human   280 GTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSE-EPIYIVTEFMCHGSLL 343
            |.|.||...|||.:|.||||...|:|||:||..|:|..|||||.|.|: .|||||||:|.|||||
  Fly   543 GKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLL 607

Human   344 DFLKNPEGQDL-RLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLI 407
            ::|:..|...: .:..|:||..||::||.|:||.|||||||.|.|.|||.....|:|||||||.:
  Fly   608 NYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYV 672

Human   408 KDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVE 472
            .||:|....|:||||||..||...:.||:.|||||::|:|:.|:.|.|::||..:...||:|:|:
  Fly   673 LDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQ 737

Human   473 QGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFL 512
            :|..:..|..|...:|:.|:..|...|||||.|..|...|
  Fly   738 RGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGR	NP_005239.1	SH3	80..137	CDD:473055	19/58 (33%)
		SH2_Src_Fgr	140..240	CDD:198230	33/100 (33%)
		Protein Kinases, catalytic domain	267..514	CDD:473864	122/248 (49%)
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	18/53 (34%)
		SH2_Tec_family	403..505	CDD:198188	34/105 (32%)
		PTKc_Tec_like	521..778	CDD:173637	124/257 (48%)