Protein Alignment FGR and yrk

DIOPT Version :9

• Sequence 1: NP_001036194.1
• Gene: FGR / 2268
• HGNCID: 3697
• Length: 529
• Species: Homo sapiens
• Sequence 2: NP_001352482.1
• Gene: yrk / 337571
• ZFINID: ZDB-GENE-030131-9517
• Length: 528
• Species: Danio rerio
• Alignment Length: 534
• Identity: 373/534 - (69%)
• Similarity: 432/534 - (80%)
• Gaps: 15/534 - (2%)

Human     1 MGCVFCKKLEPVATAKEDAGLEGDFRSYGAAD--HYGPDPTKARPASSF-AHIPNYSNFSSQAIN 62
            |||..||:.:...........:. |....|::  .|.||||       | :.|||:::||:....
Zfish     1 MGCACCKQRKASKAVSNQNSCDA-FNGTQASEPSRYIPDPT-------FNSGIPNFNDFSNPLTP 57

Human    63 P-GFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTG 126
            | ..::.....|::|.|||||||||:|:|||||||:|.|||||||:|||||||||||||.:||:|
Zfish    58 PTSIINPARPPGLTGGGVTLFIALYEYDARTEDDLSFQKGEKFHIINNTEGDWWEARSLDTGKSG 122

Human   127 CIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTR 191
            .|||||||||||||||||||||:||||||||||:..||:|.|||||||||||||||||||||..:
Zfish   123 YIPSNYVAPVDSIQAEEWYFGKMGRKDAERQLLAQNNPRGTFLIRESETTKGAYSLSIRDWDDAK 187

Human   192 GDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLA---K 253
            |||||||||||||.||||||||.||::||:||:||.|...|||..||..|....|:...|:   |
Zfish   188 GDHVKHYKIRKLDNGGYYITTRTQFDTVQQLVEHYTERAAGLCCRLIGSCRRGMPKLADLSVKTK 252

Human   254 DAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKL 318
            |.|||.|.|:.|.::||.|.||:||:|.|||:|||||||||||||||:|||:|||:||.||||||
Zfish   253 DVWEIPRESLQLIKKLGNGQFGEVWMGMWNGTTKVAVKTLKPGTMSPEAFLDEAQIMKRLRHDKL 317

Human   319 VQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDL 383
            ||||||||||||||:||||..||||||||:.:|::|:||||||||||:|.||||:||||||||||
Zfish   318 VQLYAVVSEEPIYIITEFMSQGSLLDFLKDGDGRNLKLPQLVDMAAQIAAGMAYIERMNYIHRDL 382

Human   384 RAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILL 448
            ||||||||:.|.||||||||||||:|:||...||:|||||||||||||:|:||||||||||||||
Zfish   383 RAANILVGDGLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGKFTIKSDVWSFGILL 447

Human   449 TELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLE 513
            ||||||||:||||||.||||||||:||.||||.|.||||:|.|.|.||.||:||.||||||||||
Zfish   448 TELITKGRVPYPGMNNREVLEQVERGYRMPCPQGSPASLHELMLQCWRKDPDERHTFEYLQSFLE 512

Human   514 DYFTSAEPQYQPGD 527
            ||||:.|||||||:
Zfish   513 DYFTATEPQYQPGE 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGR	NP_001036194.1	SH3	80..137	CDD:327375	47/56 (84%)
		SH2_Src_Fgr	140..240	CDD:198230	78/99 (79%)
		PKc_like	267..514	CDD:328722	198/246 (80%)
yrk	NP_001352482.1	SH3	76..133	CDD:327375	47/56 (84%)
		SH2	136..234	CDD:326550	76/97 (78%)
		PTKc_Src_Fyn_like	266..513	CDD:271105	198/246 (80%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194330711
Domainoid	1	1.000	90	1.000	Domainoid score	I27943
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3842
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52589
OrthoDB	1	1.010	-	-		D133886at7742
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100661
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.860