Protein Alignment FGR and fgr

DIOPT Version :10

• Sequence 1: NP_005239.1
• Gene: FGR / 2268
• HGNCID: 3697
• Length: 529
• Species: Homo sapiens
• Sequence 2: XP_002934688.1
• Gene: fgr / 100493811
• XenbaseID: XB-GENE-6073541
• Length: 519
• Species: Xenopus tropicalis
• Alignment Length: 532
• Identity: 384/532 - (72%)
• Similarity: 433/532 - (81%)
• Gaps: 20/532 - (3%)

Human     1 MGCVFCK--KLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQAIN- 62
            |||..||  |:|.|    |:..||       ....|.||||...|   |.....::.|.|..|.
 Frog     1 MGCKQCKEDKVEKV----EENALE-------IPQRYCPDPTSQMP---FRIQETHTPFISAGIGG 51

Human    63 --PGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKT 125
              .|....|...||:| |||.|||||||:|||||||||.|||||||:||:|||||||||||||.|
 Frog    52 VIAGSSQRGMGVGVTG-GVTQFIALYDYDARTEDDLTFKKGEKFHIINNSEGDWWEARSLSSGNT 115

Human   126 GCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQT 190
            |.||||||||::|||:::|||||||||||||.||..|||:|.|:||||||||||||||:||||.|
 Frog   116 GYIPSNYVAPMNSIQSKDWYFGKIGRKDAERLLLCEGNPRGTFMIRESETTKGAYSLSVRDWDAT 180

Human   191 RGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDA 255
            ||||.|||||||||.||:||||||||::|:|||:||.|.|||||:||..||...|||||||:|||
 Frog   181 RGDHAKHYKIRKLDNGGFYITTRVQFDTVEELVEHYSEFNDGLCHLLTNPCINQKPQTLGLSKDA 245

Human   256 WEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQ 320
            |||:|.||:|:::||.|||||||.|||||:|.||||||||.||||:|||||||:||.||||||||
 Frog   246 WEITRDSISLDKKLGQGCFGDVWKGTWNGTTNVAVKTLKPSTMSPEAFLEEAQIMKKLRHDKLVQ 310

Human   321 LYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRA 385
            |||||||||||||||||..|||||:||..||..|:|||||||:.|:|.||||:||||||||||||
 Frog   311 LYAVVSEEPIYIVTEFMTKGSLLDYLKEGEGHLLKLPQLVDMSGQIASGMAYIERMNYIHRDLRA 375

Human   386 ANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTE 450
            ||||||:.|.||||||||||||:|:||...||:|||||||||||||:|:||||||||||||::.|
 Frog   376 ANILVGDNLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGKFTIKSDVWSFGIMVCE 440

Human   451 LITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDY 515
            |:||||||||||:.||||||||:||.||.||.||.||:|.|.|.||.||||||||||||||||||
 Frog   441 LVTKGRIPYPGMSNREVLEQVERGYRMPAPPACPPSLHELMLQCWRGDPEERPTFEYLQSFLEDY 505

Human   516 FTSAEPQYQPGD 527
            ||:.||||||||
 Frog   506 FTATEPQYQPGD 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGR	NP_005239.1	SH3	80..137	CDD:473055	49/56 (88%)
		SH2_Src_Fgr	140..240	CDD:198230	77/99 (78%)
		Protein Kinases, catalytic domain	267..514	CDD:473864	196/246 (80%)
fgr	XP_002934688.1	SH3	72..125	CDD:473055	46/52 (88%)
		SH2_Src_Fgr	130..230	CDD:198230	77/99 (78%)
		PTKc_Src_Fyn_like	257..504	CDD:271105	196/246 (80%)