DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FGR and fgr

DIOPT Version :9

Sequence 1:	NP_001036194.1	Gene:	FGR / 2268	HGNCID:	3697	Length:	529	Species:	Homo sapiens
Sequence 2:	XP_002934688.1	Gene:	fgr / 100493811	XenbaseID:	XB-GENE-6073541	Length:	519	Species:	Xenopus tropicalis

Alignment Length:	532	Identity:	384/532 - (72%)
Similarity:	433/532 - (81%)	Gaps:	20/532 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGCVFCK--KLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQAIN- 62
            |||..||  |:|.|    |:..||       ....|.||||...|   |.....::.|.|..|.
Frog     1 MGCKQCKEDKVEKV----EENALE-------IPQRYCPDPTSQMP---FRIQETHTPFISAGIGG 51

Human    63 --PGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKT 125
              .|....|...||:| |||.|||||||:|||||||||.|||||||:||:|||||||||||||.|
Frog    52 VIAGSSQRGMGVGVTG-GVTQFIALYDYDARTEDDLTFKKGEKFHIINNSEGDWWEARSLSSGNT 115

Human   126 GCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQT 190
            |.||||||||::|||:::|||||||||||||.||..|||:|.|:||||||||||||||:||||.|
Frog   116 GYIPSNYVAPMNSIQSKDWYFGKIGRKDAERLLLCEGNPRGTFMIRESETTKGAYSLSVRDWDAT 180

Human   191 RGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDA 255
            ||||.|||||||||.||:||||||||::|:|||:||.|.|||||:||..||...|||||||:|||
Frog   181 RGDHAKHYKIRKLDNGGFYITTRVQFDTVEELVEHYSEFNDGLCHLLTNPCINQKPQTLGLSKDA 245

Human   256 WEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQ 320
            |||:|.||:|:::||.|||||||.|||||:|.||||||||.||||:|||||||:||.||||||||
Frog   246 WEITRDSISLDKKLGQGCFGDVWKGTWNGTTNVAVKTLKPSTMSPEAFLEEAQIMKKLRHDKLVQ 310

Human   321 LYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRA 385
            |||||||||||||||||..|||||:||..||..|:|||||||:.|:|.||||:||||||||||||
Frog   311 LYAVVSEEPIYIVTEFMTKGSLLDYLKEGEGHLLKLPQLVDMSGQIASGMAYIERMNYIHRDLRA 375

Human   386 ANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTE 450
            ||||||:.|.||||||||||||:|:||...||:|||||||||||||:|:||||||||||||::.|
Frog   376 ANILVGDNLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGKFTIKSDVWSFGIMVCE 440

Human   451 LITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDY 515
            |:||||||||||:.||||||||:||.||.||.||.||:|.|.|.||.||||||||||||||||||
Frog   441 LVTKGRIPYPGMSNREVLEQVERGYRMPAPPACPPSLHELMLQCWRGDPEERPTFEYLQSFLEDY 505

Human   516 FTSAEPQYQPGD 527
            ||:.||||||||
Frog   506 FTATEPQYQPGD 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FGR	NP_001036194.1	SH3	80..137	CDD:327375	49/56 (88%)
		SH2_Src_Fgr	140..240	CDD:198230	77/99 (78%)
		PKc_like	267..514	CDD:328722	196/246 (80%)
fgr	XP_002934688.1	SH3	72..125	CDD:388381	46/52 (88%)
		SH2_Src_Fgr	130..230	CDD:198230	77/99 (78%)
		PTKc_Src_Fyn_like	257..504	CDD:271105	196/246 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I31135
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3842
Inparanoid	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101062at32523
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1168
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.110