DRSC/TRiP Functional Genomics Resources

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Protein Alignment FGG and CG41520

DIOPT Version :10

Sequence 1:NP_068656.2 Gene:FGG / 2266 HGNCID:3694 Length:453 Species:Homo sapiens
Sequence 2:NP_001104019.1 Gene:CG41520 / 5740294 FlyBaseID:FBgn0087011 Length:745 Species:Drosophila melanogaster


Alignment Length:381 Identity:117/381 - (30%)
Similarity:172/381 - (45%) Gaps:79/381 - (20%)


- Green bases have known domain annotations that are detailed below.


Human    58 YQTK--VDKD--------LQSLEDILHQVENKTSEVKQLIKAIQLTYNPDESSKPNMIDAATLKS 112
            |::|  .|.|        |.||.:|...:.|||.       ....|..|.:......:.:.:|.|
  Fly   407 YESKNYTDTDENSRTEILLLSLSNIQPTIVNKTI-------TTPFTSTPGDGDVLGPLHSESLDS 464

Human   113 RKMLEEIMKYEASILTHDSSIRYLQEIYNS---NNQKIVNLKEKVAQLEAQCQEPC-------KD 167
            .:             ||          ||.   |..|..|.|:::. ..:..::|.       .|
  Fly   465 NR-------------TH----------YNGPAVNGLKSANRKDRII-FPSIKKKPAFLNTTISND 505

Human   168 TVQIHDITGKDCQDIANKGAKQSGLYFIKPLKANQQFL-VYCEIDGSGNGWTVFQKR---LDGSV 228
            ...:.|:.|..|.||.|.|.||||:::::.......|| |||:.:.:..||||.|:|   .|...
  Fly   506 FWALKDVKGFSCVDILNAGMKQSGVFYLQIRGTTYWFLKVYCDQETTDGGWTVIQRRDDFKDSRE 570

Human   229 DFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADYAMFKV 293
            :|.::|..||.|||..|    .:||||||.|::::...  .|:|||||||:.|....|.|:.||:
  Fly   571 NFNRDWADYKNGFGEPS----KDFWLGNENIYMLTNNE--EYSLRVELEDFEGNKRYAQYSHFKI 629

Human   294 GPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGS 358
            ..|||.|:|..         |.::| :.||..:|.::.|:|. .|||::.|||:...|||.....
  Fly   630 HSEADYYKLEI---------DGYEG-NAGDSLNDPWYGSNNS-PFSTYNKDNDRSSLNCASMLKG 683

Human   359 GWWMNKCHAGHLNGVYYQGGTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIP 414
            |||...|..| |||:|........|.      .||:|..|:...|::||:.|.|.|
  Fly   684 GWWWKSCGRG-LNGLYLHDPQDITAR------QGIVWFRWRGWDYTLKKSKMMIRP 732

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FGGNP_068656.2 Fib_alpha 30..172 CDD:462570 25/133 (19%)
Fibrinogen_C 175..414 CDD:395095 90/242 (37%)
Gamma-chain polymerization, binding amino end of another fibrin alpha chain 400..422 6/15 (40%)
Platelet aggregation and Staphylococcus clumping 423..437
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 424..453
CG41520NP_001104019.1 FReD 516..733 CDD:238040 90/241 (37%)
Blue background indicates that the domain is not in the aligned region.

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