DRSC/TRiP Functional Genomics Resources

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Protein Alignment FGG and CG9593

DIOPT Version :10

Sequence 1:NP_068656.2 Gene:FGG / 2266 HGNCID:3694 Length:453 Species:Homo sapiens
Sequence 2:NP_650493.2 Gene:CG9593 / 41912 FlyBaseID:FBgn0038365 Length:382 Species:Drosophila melanogaster


Alignment Length:377 Identity:108/377 - (28%)
Similarity:161/377 - (42%) Gaps:83/377 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    66 LQSLEDILHQVENKTSEVKQLIKAIQLTYNPDESSKPNMIDAATLKSR-KMLEEIMKYEASILTH 129
            |:.||..||:|.:|...:...:..:...|    |||.:.:  |.|..| .:|.|.:..|..|.|:
  Fly    53 LRGLEINLHRVLSKVVLLADAVVQVPGRY----SSKEDPL--AVLSERLNLLLERLNQEERISTN 111

Human   130 DSSIRYLQEIYNSNNQKIVNLKEKVAQLEAQCQEPC------------KD--TVQIHDITGKDCQ 180
                             ::.|||...::   ||||.            ||  .|..:.....||.
  Fly   112 -----------------LLELKEWSTKV---CQEPSPSQTLPKELTEEKDEPKVDFYQPAKSDCH 156

Human   181 DIANKGAKQSGLY-FIKPLKANQQ---FLVYCEIDGSGNGWTVFQKRLDGSVD----FKKNWIQY 237
            :: ::|.:..|:| |:.|.:...|   :..||.....|..|||.|.| .||.|    |.::|.:|
  Fly   157 EL-DEGVRVDGVYRFLVPERNEVQRDLYERYCAFATDGPAWTVIQSR-GGSFDPHENFNRSWDEY 219

Human   238 KEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADYAMFKVGPEADKYRL 302
            :.|||:||    .:||.|||..|.|..:.  .:.||:||::.......|:|.:|.:..|:..|:|
  Fly   220 RAGFGNLS----RDFWFGNEFAHKILYRD--DHELRIELQEAGEPLDWAEYPLFWLDSESYNYQL 278

Human   303 TYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWD---NDNDKFEGNCAEQDGSGWWMNK 364
            :.|....|...||.:              .||.|.|||:|   |.....:..|.|..|.|||.::
  Fly   279 SVAGEFRGSLPDALE--------------QHNRMDFSTYDRRRNHAKSADSTCGEDYGGGWWFDR 329

Human   365 CHAGHLNGVYYQGGTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIPFN 416
            |...:|||   :.|.:.:||.      .|||..|:|.....|.:.|.|.|.|
  Fly   330 CTQCNLNG---EHGVHQRASP------AIIWMNWRTGTDKPKSSRMMIRPVN 372

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FGGNP_068656.2 Fib_alpha 30..172 CDD:462570 29/120 (24%)
Fibrinogen_C 175..414 CDD:395095 77/249 (31%)
Gamma-chain polymerization, binding amino end of another fibrin alpha chain 400..422 6/17 (35%)
Platelet aggregation and Staphylococcus clumping 423..437
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 424..453
CG9593NP_650493.2 FReD 150..371 CDD:238040 77/251 (31%)
Blue background indicates that the domain is not in the aligned region.

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