Protein Alignment FGG and CG10359

DIOPT Version :10

• Sequence 1: NP_068656.2
• Gene: FGG / 2266
• HGNCID: 3694
• Length: 453
• Species: Homo sapiens
• Sequence 2: NP_001137882.1
• Gene: CG10359 / 38434
• FlyBaseID: FBgn0035452
• Length: 485
• Species: Drosophila melanogaster
• Alignment Length: 458
• Identity: 105/458 - (22%)
• Similarity: 181/458 - (39%)
• Gaps: 128/458 - (27%)

Human    49 CGIADFLSTYQTKV------DKD----LQSLEDILHQVENKTSEVKQLIKAIQLTY--------- 94
            |...:.::....:|      |:|    |:.::..|.|:...:|...:.:||.||.:
  Fly    67 CDYKELMTNLHDRVGILVTLDEDQRHRLEVIDKKLDQLVESSSARMESMKAQQLDFLHRLDSFEH 131

Human    95 --------------NPDESSKPNMIDAA--TLKSRKMLEEIMKYEASILTHDSSIRYLQEIYNSN 143
                          ..|:...|..:...  .|::||.:::|     |....|.|    ||.|.|:
  Fly   132 IQRLSRNTLDELKGETDQVFGPRNVRELKHKLRNRKKMKDI-----SRTVRDVS----QEQYPSS 187

Human   144 -----NQKIVNLKEK---VAQLEAQCQEPCKDT-VQIHDIT---GKDCQDIANKGAKQS------ 190
                 |:..:||..:   :|.|.|......:.. |::.:::   .:..:.|..||.:.:
  Fly   188 GIGTFNESNLNLSSRLDALATLLASTALSVRSVQVEVANLSRAIRRQSRLIQGKGLRSTPGQQPI 252

Human   191 ----------------------------GLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGS 227
                                        |:..::....::.|.|.|:.|     |||...|....
  Fly   253 FYGPSGLNGPTATRQLPSSCSYSFLSNHGILKVQLTPESESFYVSCDED-----WTVILSRTSDD 312

Human   228 VDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADYAMFK 292
            |:|::.|:.|::|||:|:    .:|::|..|:|.: |.||: :.||:.:||::|..:.|.|::|.
  Fly   313 VNFERGWLDYRDGFGNLA----GDFFIGLNKLHAL-TSSAL-HELRIVMEDFSGNVAYAGYSLFA 371

Human   293 VGPEADKYRLT-YAYFAGGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWDNDNDK-FEGNCAEQ 355
            :|.|.:.|.|. ...|.......|.|...:           |.|.:|||.|.|||. .|.|||.:
  Fly   372 IGSEKELYPLVLLGKFQDNLTPSAGDSLSY-----------HAGAKFSTVDQDNDNCLECNCALR 425

Human   356 DGSGWWMNKCHAGHLNGVYYQGGTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRLTI 420
            .....|.|.|...:|      .|.|:..:.|.  :.||.|.|:..: .|:|:....|.|     |
  Fly   426 HKGAGWFNNCAKSNL------FGEYTTQNQPG--ETGIWWDTFSGQ-NSLKRVRWMIRP-----I 476

Human   421 GEG 423
            .||
  Fly   477 SEG 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGG	NP_068656.2	Fib_alpha	30..172	CDD:462570	32/166 (19%)
		Fibrinogen_C	175..414	CDD:395095	69/277 (25%)
		Gamma-chain polymerization, binding amino end of another fibrin alpha chain	400..422		5/21 (24%)
		Platelet aggregation and Staphylococcus clumping	423..437		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	424..453		105/458 (23%)
CG10359	NP_001137882.1	FReD	267..476	CDD:238040	67/244 (27%)