Protein Alignment FGG and sca

DIOPT Version :10

• Sequence 1: NP_068656.2
• Gene: FGG / 2266
• HGNCID: 3694
• Length: 453
• Species: Homo sapiens
• Sequence 2: NP_476710.2
• Gene: sca / 36411
• FlyBaseID: FBgn0003326
• Length: 799
• Species: Drosophila melanogaster
• Alignment Length: 427
• Identity: 109/427 - (25%)
• Similarity: 175/427 - (40%)
• Gaps: 98/427 - (22%)

Human    59 QTKVDKDLQSLEDILHQVENKTSEV---KQLIKAIQLTYNPDESSKPNMIDAATLKSRKMLEEIM 120
            |||:||.:..|...:.::|...:::   :.||:  :...|...|.:...:..:.|:..:  |.:.
  Fly   398 QTKMDKSIPELRHEISKLEFANAQITSEQSLIR--EEGTNAARSLQAMAVSVSVLQEER--EGMR 458

Human   121 KYEASILTHDSSIRYLQEIYNSNNQKIVNLKEKVAQL----------EAQCQEPCKDT------- 168
            |..|::....:::..||.:.|.      .:|.|:..|          ..|.|.|..|:
  Fly   459 KLSANVDQLRTNVDRLQSLVND------EMKNKLTHLNKPHKRPHHQNVQAQMPQDDSPIDSVLA 517

Human   169 -----------VQIHDITGK---DCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTV 219
                       .|...|..|   ||.::   ..:..||:.|.|.......:.:|..|    |||.
  Fly   518 ETLVSELENVETQYEAIINKLPHDCSEV---HTQTDGLHLIAPAGQRHPLMTHCTAD----GWTT 575

Human   220 FQKRLDGSVDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTS 284
            .|:|.|||.||.::|..|.:|||  :|.|  |||:|||::|.::..:.  ..|:|:::|......
  Fly   576 VQRRFDGSADFNRSWADYAQGFG--APGG--EFWIGNEQLHHLTLDNC--SRLQVQMQDIYDNVW 634

Human   285 TADYAMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWDNDNDKFE 349
            .|:|..|.:...||.|||..|.:: |:|.||.:              ...|||||..|:|.|..:
  Fly   635 VAEYKRFYISSRADGYRLHIAEYS-GNASDALN--------------YQQGMQFSAIDDDRDISQ 684

Human   350 GNCAEQDGSGWWMNKCHAGHLNGVYYQGGTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIP 414
            .:||.....|||.:.|...:|||.|..|.|:..|:              :..|.::|.:.|.:
  Fly   685 THCAANYEGGWWFSHCQHANLNGRYNLGLTWFDAA--------------RNEWIAVKSSRMLV-- 733

Human   415 FNRLTIGEGQQHH---------LGGAKQVRPEHPAET 442
             .||...|.|.:.         .|.|....|...|.|
  Fly   734 -KRLPAVECQANASASGAFVSVSGSAADAAPSSGATT 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGG	NP_068656.2	Fib_alpha	30..172	CDD:462570	26/143 (18%)
		Fibrinogen_C	175..414	CDD:395095	73/241 (30%)
		Gamma-chain polymerization, binding amino end of another fibrin alpha chain	400..422		5/21 (24%)
		Platelet aggregation and Staphylococcus clumping	423..437		3/22 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	424..453		6/28 (21%)
sca	NP_476710.2	PRK03918	134..>485	CDD:235175	19/96 (20%)
		FBG	538..736	CDD:214548	72/242 (30%)