Protein Alignment FGG and CG8642

DIOPT Version :10

• Sequence 1: NP_068656.2
• Gene: FGG / 2266
• HGNCID: 3694
• Length: 453
• Species: Homo sapiens
• Sequence 2: NP_610396.2
• Gene: CG8642 / 35845
• FlyBaseID: FBgn0033312
• Length: 429
• Species: Drosophila melanogaster
• Alignment Length: 388
• Identity: 116/388 - (29%)
• Similarity: 177/388 - (45%)
• Gaps: 50/388 - (12%)

Human    36 ILDERFGSYCPTTCGIADFLSTYQTKVDKDLQSLEDILHQVENKTSEVKQLIKAIQLTYNPDESS 100
            :||...|....:...|.|..:.......|| |:.:::|.:.||.|    |:..|.|.::......
  Fly    78 LLDVYMGKIAESAATIKDKENEINKLQTKD-QTGDELLRKFENLT----QVCSAQQSSFTTAIKE 137

Human   101 KPNMIDAATLKSRKMLEEIMK-YEASILTHDSSIRYLQEIYNSNNQKIVNLKEKVAQLEAQCQEP 164
            |...|        |.||:.:| ||..:......:..|:::..|:...|.:||.||...|.:.:|.
  Fly   138 KDEQI--------KELEQKVKVYETRLKRKQHVLAELRKLNGSSALLIEHLKGKVVYFERKFREK 194

Human   165 CKDTVQIHDITGKDCQDIANKGAKQSGLYFIKPLKANQQFLVYCE-IDGSGNGWTVFQKRLDGSV 228
            ..|.:...:.....|...    .:..|::.|. |.....|||.|| ...:|.|||..|:||||||
  Fly   195 KDDLLADWEAATTSCVPF----GRSPGIHLIH-LPGFLPFLVPCEGQTAAGPGWTCIQRRLDGSV 254

Human   229 DFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADYAMFKV 293
            :|.:||..|.:|||.|:    .||::|.||:|.::  |:.|:.|.:.:..:.|.||.|.|..|.:
  Fly   255 NFYRNWDAYSKGFGKLN----GEFFIGLEKLHRLT--SSQPHELYISIRRFGGETSYAHYDDFLI 313

Human   294 GPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWDNDNDKF-EGNCAEQDG 357
            |.|.:.|.|.......|:|.||              ..:|:.|:|||:|.|||.| ..||||...
  Fly   314 GSEEEGYELKLLGHYQGNASDA--------------LRTHDKMKFSTYDRDNDAFTHMNCAEHHQ 364

Human   358 SGWWMNKCHAGHLNGVYYQGGTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRLTI 420
            ..||.:.|...:|||.|::|    :...|    ..|.|..|.: :.|:|...|.|.|.::|.:
  Fly   365 GAWWYDFCSRSNLNGRYFKG----EVDNP----QSIYWEPWYS-FRSLKSVQMLIRPKSQLEL 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGG	NP_068656.2	Fib_alpha	30..172	CDD:462570	33/136 (24%)
		Fibrinogen_C	175..414	CDD:395095	81/240 (34%)
		Gamma-chain polymerization, binding amino end of another fibrin alpha chain	400..422		6/21 (29%)
		Platelet aggregation and Staphylococcus clumping	423..437
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	424..453
CG8642	NP_610396.2	MAD	71..>198	CDD:461677	32/132 (24%)
		FReD	213..413	CDD:238040	80/229 (35%)