DRSC/TRiP Functional Genomics Resources

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Protein Alignment FGG and CG6788

DIOPT Version :10

Sequence 1:NP_068656.2 Gene:FGG / 2266 HGNCID:3694 Length:453 Species:Homo sapiens
Sequence 2:NP_573254.1 Gene:CG6788 / 32773 FlyBaseID:FBgn0030880 Length:358 Species:Drosophila melanogaster


Alignment Length:424 Identity:120/424 - (28%)
Similarity:187/424 - (44%) Gaps:101/424 - (23%)


- Green bases have known domain annotations that are detailed below.


Human    15 YALLFLS---STCVA------YVATRDNCC----------ILDERFGSYCPTTCGIADFLSTYQT 60
            |.:|.||   ||.:|      :....||.|          ||| ||..     ...:|.|   :.
  Fly     9 YLILILSLSISTSLANDPQRSFDQNADNPCSAHRIWVWRPILD-RFAK-----VNSSDEL---KN 64

Human    61 KVDKDLQSLEDILHQVENKTSEVKQLIKAIQLTYNPDESSKPNMIDAATLKSRKML-EEIMKYEA 124
            :|:...::::|:..::.:|...:  |::|.|:   .|:|::.|::    :|:.|:| .|.:..:|
  Fly    65 QVNAMSETIKDLQTRIGHKNELL--LLQAGQI---KDQSARLNVL----IKNMKVLRSECLNAQA 120

Human   125 SILTHDSSIRYLQEIYNSNNQKIVNLKEKVAQLEAQC--QEPCKDTVQIHDITGKDCQDIANKGA 187
            .|.:.|..|:.          ....:|:...:|..||  |:.|       .|.||          
  Fly   121 EIKSKDIQIQL----------SAAKIKQMSNELVTQCSRQDTC-------PIDGK---------- 158

Human   188 KQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEGFGHLSPTGTTEF 252
              .|:|.:| ::....|...|    |.|||...|||.||:.:|.:.|..||:|||.:    ..||
  Fly   159 --GGIYKLK-IRELPAFEAPC----SSNGWLTIQKRYDGAENFDRGWKDYKDGFGRV----RGEF 212

Human   253 WLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADYAMFKVGPEADKYRLTYAYFAGGDAGDAFD 317
            ::|.||:||::.|..  :.|.::|...:|.||.|.|..|::|.|.:.|.|.......|.|||:  
  Fly   213 FIGLEKVHLMTRQRR--HELYIKLGKIDGTTSHAHYDNFELGGEIESYELKSLGRYNGTAGDS-- 273

Human   318 GFDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQGGTYSK 382
                        ...|...:|:|.|.|||.:..|||..:..|||...|....|||.:|:.|    
  Fly   274 ------------LRPHERQKFTTNDKDNDAYRFNCAADEYGGWWYYDCAKSMLNGKFYKEG---- 322

Human   383 ASTPNGYDNGIIWATWKTR-W-YSMKKTTMKIIP 414
             .:.||..|||:|.:|... | ||:....|.|.|
  Fly   323 -RSRNGKTNGILWGSWHNNDWTYSLTFVEMMIRP 355

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FGGNP_068656.2 Fib_alpha 30..172 CDD:462570 33/154 (21%)
Fibrinogen_C 175..414 CDD:395095 78/240 (33%)
Gamma-chain polymerization, binding amino end of another fibrin alpha chain 400..422 6/17 (35%)
Platelet aggregation and Staphylococcus clumping 423..437
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 424..453
CG6788NP_573254.1 FReD 160..356 CDD:238040 77/226 (34%)
Blue background indicates that the domain is not in the aligned region.

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