DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FGG and CG31832

DIOPT Version :9

Sequence 1:	NP_068656.2	Gene:	FGG / 2266	HGNCID:	3694	Length:	453	Species:	Homo sapiens
Sequence 2:	NP_723894.2	Gene:	CG31832 / 318970	FlyBaseID:	FBgn0051832	Length:	227	Species:	Drosophila melanogaster

Alignment Length:	221	Identity:	73/221 - (33%)
Similarity:	109/221 - (49%)	Gaps:	34/221 - (15%)

- Green bases have known domain annotations that are detailed below.

Human   179 CQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEGFGH 243
            |...:..|..|..|...:|.:..|     |:.  :...|.|.|:||||||:|.::|..||:|||
  Fly    25 CPSGSPNGIHQLMLPEEEPFQVTQ-----CKT--TARDWIVIQRRLDGSVNFNQSWFSYKDGFG- 81

Human   244 LSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADYAMFKVGPEADKYRLTYAYFA 308
             .|.|  ||::|.:|::|::.:.  |:.|.::|:...|.|..|.:..|:|..|.:.|:|......
  Fly    82 -DPNG--EFFIGLQKLYLMTREQ--PHELFIQLKHGPGATVYAHFDDFQVDSETELYKLERVGKY 141

Human   309 GGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGV 373
            .|.|||:              ...|...:|||:|.|||:...|||.:.|.|||.:.|.:..|||:
  Fly   142 SGTAGDS--------------LRYHINKRFSTFDRDNDESSKNCAAEHGGGWWFHSCLSSSLNGL 192

Human   374 YYQGGTYSKASTPNGYDNGIIWATWK 399
            |::.|       ..|..|||.|..||
  Fly   193 YFREG-------ETGMLNGIHWGRWK 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FGG	NP_068656.2	Fib_alpha	31..172	CDD:285864
		FReD	175..414	CDD:294064	73/221 (33%)
		Gamma-chain polymerization, binding amino end of another fibrin alpha chain	400..422		73/221 (33%)
		Platelet aggregation and Staphylococcus clumping	423..437
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..453
CG31832	NP_723894.2	FReD	28..225	CDD:238040	72/218 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	168	1.000	Inparanoid score	I4150
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860