Protein Alignment FGFR4 and Alk

DIOPT Version :10

• Sequence 1: NP_002002.3
• Gene: FGFR4 / 2264
• HGNCID: 3691
• Length: 802
• Species: Homo sapiens
• Sequence 2: NP_652600.1
• Gene: Alk / 53425
• FlyBaseID: FBgn0040505
• Length: 1701
• Species: Drosophila melanogaster
• Alignment Length: 658
• Identity: 183/658 - (27%)
• Similarity: 279/658 - (42%)
• Gaps: 164/658 - (24%)

Human   213 SVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGL-----PANT----TAVVGSDVE 268
            :::...||.::|.||.|...           .|.||. .|.|.     ..||    ....|.||.
  Fly   960 ALLQGGRGGHSCYVELADNG-----------TSVHRH-GQGGFGGGGGGCNTGGGGGGYAGGDVY 1012

Human   269 LLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAG---- 329
            |.                     .|.|..|..|:...::            ||.:|...||
  Fly  1013 LT---------------------ESNGEGGSSYISPSRS------------LREISEIHAGASSG 1044

Human   330 ---------------EYTCLAGNSIGLSYQSAWLTVLPEEDPTW-------TAA-----APEARY 367
                           :|.|:|.:    .::|....:.|:   .|       ||.     |.::.:
  Fly  1045 PGAIIIIPAIEGCGCDYRCVALD----EFRSKVRCICPD---GWSLKRDNHTACEIREEAGKSSF 1102

Human   368 TDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSL 432
            ..::.....|||:..:.:.|.::   .|:.|:.|...: :|..:..:.:...|....:....|:
  Fly  1103 QYLVSILMISLAVLFICIAALIF---MLYNRYQRKKQS-KKRHKMLVEQDLQLTRLRNNIDDSN- 1162

Human   433 VRGVRLSSSGPAL-LAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRA-------EAFGM 489
                 |::..|.. ..|:::..:.::.|.:..||.|.|...||:|.||:|..|       :|..|
  Fly  1163 -----LNNFNPNYGCDGILNGHIDVNSLPQVARDSLQLVNALGKGAFGEVYMALYRHRDGDAVEM 1222

Human   490 DPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAA 554
            .         ||||.|:::...:...|.:.|..:|... .|.|:::|:|||....|.|:::|..|
  Fly  1223 G---------VAVKTLREDPKREKEEDFLKEAAIMAKF-NHPNMVHLIGVCFDRQPYYIVLELLA 1277

Human   555 KGNLREFLRARR--PPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARN 617
            .|:|::|||..|  |..|.|           |:...|:.||..||:|.:|:||::.||||:||||
  Fly  1278 GGDLQKFLRENRNTPERPSL-----------LTMKDLLFCALDVAKGCRYMESKRFIHRDIAARN 1331

Human   618 VLVTE---DNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILL 679
            .|::.   ..|:||||||::|.::..|||:|.....||:|||.|||..|.::|.::|||||||||
  Fly  1332 CLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILL 1396

Human   680 WEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALD 744
            ||:|:||.|||||....::..|:..|.|:..|..||..:|.:|.:||:..|..||||..|:|.|.
  Fly  1397 WEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHLT 1461

Human   745 KVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHD---------------PLPLGSSSF 794
            ......|.....|....||          |.|..|......               |||.|.|:.
  Fly  1462 ACTQDASIMNAPLPNILGP----------TASERDDTVIRPPNGEEFCLAVPDYLVPLPPGGSNN 1516

Human   795 P---FGSG 799
            |   .|||
  Fly  1517 PSMASGSG 1524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGFR4	NP_002002.3	Ig_3	36..104	CDD:464046
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	119..148
		IgI_2_FGFR	147..241	CDD:409443	6/27 (22%)
		Ig strand A	147..150	CDD:409443
		Ig strand A'	158..163	CDD:409443
		Ig strand B	167..175	CDD:409443
		Ig strand C	181..186	CDD:409443
		Ig strand C'	189..191	CDD:409443
		Ig strand D	200..203	CDD:409443
		Ig strand E	207..212	CDD:409443
		Ig strand F	221..228	CDD:409443	2/6 (33%)
		Ig strand G	231..241	CDD:409443	0/9 (0%)
		Ig	249..351	CDD:472250	21/129 (16%)
		Ig strand B	267..271	CDD:409444	2/3 (67%)
		Ig strand C	280..284	CDD:409444	0/3 (0%)
		Ig strand E	316..320	CDD:409444	0/3 (0%)
		Ig strand F	330..335	CDD:409444	2/4 (50%)
		Ig strand G	343..346	CDD:409444	0/2 (0%)
		Protein Kinases, catalytic domain	454..767	CDD:473864	123/324 (38%)
Alk	NP_652600.1	MAM	288..447	CDD:99706
		MAM	505..689	CDD:99706
		PTKc_ALK_LTK	1186..1462	CDD:270632	118/296 (40%)