DRSC/TRiP Functional Genomics Resources

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Protein Alignment FGFR4 and Src64B

DIOPT Version :10

Sequence 1:NP_002002.3 Gene:FGFR4 / 2264 HGNCID:3691 Length:802 Species:Homo sapiens
Sequence 2:NP_001286937.1 Gene:Src64B / 48973 FlyBaseID:FBgn0262733 Length:553 Species:Drosophila melanogaster


Alignment Length:617 Identity:179/617 - (29%)
Similarity:261/617 - (42%) Gaps:159/617 - (25%)


- Green bases have known domain annotations that are detailed below.


Human   180 PTIRWLKDGQAF-------HGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNY 237
            ||..:.|....|       .|...:||: |..:|                     |..||:...|
  Fly    19 PTGGYKKSDYTFGQTHINSSGGGNMGGV-LGQKH---------------------NNGGSLDSRY 61

Human   238 LLDVLERSPHRPILQAGL----PANT-TAVVG------------------SDVELL----CKVYS 275
            ..|...|.|.:...:.|:    |..| |.|.|                  ||:..:    .:|..
  Fly    62 TPDPNHRGPLKIGGKGGVDIIRPRTTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVID 126

Human   276 DAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIG 340
            |.:.  .|.:  |:|.::......|...|.:...:||   |..:..||..::|.:          
  Fly   127 DTES--DWWR--VVNLTTRQEGLIPLNFVAEERSVNS---EDWFFENVLRKEADK---------- 174

Human   341 LSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPR-PPA 404
                    .:|.||:|..|.....:.:.      ....:|:|    .....|:..|.:|.| .| 
  Fly   175 --------LLLAEENPRGTFLVRPSEHN------PNGYSLSV----KDWEDGRGYHVKHYRIKP- 220

Human   405 TVQKLSRFPLARQFSLESG----SSGKSSSSLVRGVRLSSSGPAL-LAGLVSLDLP--------- 455
                           |::|    ::.::..||...|...|...|| |..::|...|         
  Fly   221 ---------------LDNGGYYIATNQTFPSLQALVMAYSKENALGLCHILSRPCPKPQPQMWDL 270

Human   456 ---LDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADL 517
               |...:|.||..:.|.:.||.|.||:|.    :|    :...:..||||.|::..  ...|..
  Fly   271 GPELRDKYEIPRSEIQLLRKLGRGNFGEVF----YG----KWRNSIDVAVKTLREGT--MSTAAF 325

Human   518 VSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEG 582
            :.|..:||.. ||..::.|..||:||.|:|::.|..:||:|.:|||                 ||
  Fly   326 LQEAAIMKKF-RHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLR-----------------EG 372

Human   583 P---LSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYK 644
            .   |.|..|:..|.|||.||:||||::.|||||||||||:.|:||.||.||||||.:...:|..
  Fly   373 DGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCP 437

Human   645 KTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMD 709
            | ...|.||||.||||:....::.:|||||:||||.|:||.|..||||:...|:...:..|.||.
  Fly   438 K-QGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMP 501

Human   710 RPP--HCPPELYGLMRECWHAAPSQRPTFKQL 739
            :|.  :.|..:|.|:.:||.|.|.:||||:.|
  Fly   502 KPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFL 533

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FGFR4NP_002002.3 Ig_3 36..104 CDD:464046
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 119..148
IgI_2_FGFR 147..241 CDD:409443 13/67 (19%)
Ig strand A 147..150 CDD:409443
Ig strand A' 158..163 CDD:409443
Ig strand B 167..175 CDD:409443
Ig strand C 181..186 CDD:409443 1/4 (25%)
Ig strand C' 189..191 CDD:409443 0/1 (0%)
Ig strand D 200..203 CDD:409443 0/2 (0%)
Ig strand E 207..212 CDD:409443 0/4 (0%)
Ig strand F 221..228 CDD:409443 0/6 (0%)
Ig strand G 231..241 CDD:409443 3/9 (33%)
Ig 249..351 CDD:472250 21/128 (16%)
Ig strand B 267..271 CDD:409444 0/7 (0%)
Ig strand C 280..284 CDD:409444 0/3 (0%)
Ig strand E 316..320 CDD:409444 1/3 (33%)
Ig strand F 330..335 CDD:409444 0/4 (0%)
Ig strand G 343..346 CDD:409444 0/2 (0%)
Protein Kinases, catalytic domain 454..767 CDD:473864 120/303 (40%)
Src64BNP_001286937.1 SH2_Src_family 158..259 CDD:199827 28/147 (19%)
PTKc_Src_like 289..538 CDD:270630 114/274 (42%)
SH3_Src_like 99..150 CDD:212779 8/54 (15%)
Blue background indicates that the domain is not in the aligned region.

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