Protein Alignment FGFR4 and Abl

DIOPT Version :10

• Sequence 1: NP_002002.3
• Gene: FGFR4 / 2264
• HGNCID: 3691
• Length: 802
• Species: Homo sapiens
• Sequence 2: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Alignment Length: 659
• Identity: 200/659 - (30%)
• Similarity: 294/659 - (44%)
• Gaps: 161/659 - (24%)

Human   234 RYNYLLDVLERS---PHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFG 295
            :|:..|:.|.:|   ||       :||.:||     ..||... ::.|.|.|....:.:.|||.|
  Fly   124 KYHMNLEALLQSRPLPH-------IPAGSTA-----ASLLADA-AELQQHQQDSGGLGLQGSSLG 175

Human   296 ADGFPYVQVLKTADINSSEVEVL--------------------------------YLRNVSAEDA 328
            ........|.::|...:|:..:|                                .:|.:|...:
  Fly   176 GGHSSTTSVFESAHRWTSKENLLAPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKS 240

Human   329 GEYTCLAGNSIGLSYQSAWLT---VLP---EEDPTWTAAAPEARYTDIILYASG----------- 376
            ||: |.|.:..|   ...|:.   |.|   .|..:| ...|.:|.....|.:||
  Fly   241 GEW-CEAHSDSG---NVGWVPSNYVTPLNSLEKHSW-YHGPISRNAAEYLLSSGINGSFLVRESE 300

Human   377 ------SLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRG 435
                  |::|.        |.|:..|.|          :|..|..:.|..:. :...:.:.||..
  Fly   301 SSPGQRSISLR--------YEGRVYHYR----------ISEDPDGKVFVTQE-AKFNTLAELVHH 346

Human   436 VRLSSSGPALLAGLV--------SLDLPLDP---LWEFPRDRLVLGKPLGEGCFGQVVRA--EAF 487
            ..:...|..|:..|:        ....||.|   .||..|..:::...||.|.:|:|..|  :.:
  Fly   347 HSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRY 411

Human   488 GMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVEC 552
            |         :|||||.||::.  ..|.|.:.|..:||.: :|.|::.|:||||:|.|.|:|.|.
  Fly   412 G---------NTVAVKTLKEDT--MALKDFLEEAAIMKEM-KHPNLVQLIGVCTREPPFYIITEF 464

Human   553 AAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARN 617
            .:.|||.:|||:              :....|....|:..|.|:|.||.|||||..|||||||||
  Fly   465 MSHGNLLDFLRS--------------AGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARN 515

Human   618 VLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEI 682
            .||.::.::|:||||||| :...|.|...:..:.|:||.|||.|....::.:||||:||:|||||
  Fly   516 CLVGDNKLVKVADFGLAR-LMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEI 579

Human   683 FTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 747
            .|.|.||||.|.:.:::..|.:|:||:|||.||||:|.|||:||....:.|||||.:..||:.:.
  Fly   580 ATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMF 644

Human   748 LAVS-----EEYLDLRLTFGPYS-PS------GGDASST-----CSSSDSV---FSHDP------ 786
            ...|     |:.|:...|....| ||      ||.|::|     |:||.|.   .|..|
  Fly   645 QESSITEAVEKQLNANATSASSSAPSTSGVATGGGATTTTAASGCASSSSATASLSLTPQMVKKG 709

Human   787 LPLGSSSFP 795
            ||.|.:..|
  Fly   710 LPGGQALTP 718

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGFR4	NP_002002.3	Ig_3	36..104	CDD:464046
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	119..148
		IgI_2_FGFR	147..241	CDD:409443	2/6 (33%)
		Ig strand A	147..150	CDD:409443
		Ig strand A'	158..163	CDD:409443
		Ig strand B	167..175	CDD:409443
		Ig strand C	181..186	CDD:409443
		Ig strand C'	189..191	CDD:409443
		Ig strand D	200..203	CDD:409443
		Ig strand E	207..212	CDD:409443
		Ig strand F	221..228	CDD:409443
		Ig strand G	231..241	CDD:409443	2/6 (33%)
		Ig	249..351	CDD:472250	25/136 (18%)
		Ig strand B	267..271	CDD:409444	1/3 (33%)
		Ig strand C	280..284	CDD:409444	2/3 (67%)
		Ig strand E	316..320	CDD:409444	1/35 (3%)
		Ig strand F	330..335	CDD:409444	2/4 (50%)
		Ig strand G	343..346	CDD:409444	0/2 (0%)
		Protein Kinases, catalytic domain	454..767	CDD:473864	130/323 (40%)
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	9/57 (16%)
		SH2_ABL	268..363	CDD:198189	21/114 (18%)
		PTKc_Abl	382..644	CDD:270645	122/288 (42%)
		FABD	1584..1723	CDD:197885