DRSC/TRiP Functional Genomics Resources

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Protein Alignment FGFR4 and drl

DIOPT Version :10

Sequence 1:NP_002002.3 Gene:FGFR4 / 2264 HGNCID:3691 Length:802 Species:Homo sapiens
Sequence 2:NP_001260566.1 Gene:drl / 44355 FlyBaseID:FBgn0015380 Length:645 Species:Drosophila melanogaster


Alignment Length:591 Identity:135/591 - (22%)
Similarity:232/591 - (39%) Gaps:142/591 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   195 NRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANT 259
            :|||.:.:..|.|.:.::.     .||     .||..::..|..: :|:|:.:.         ||
  Fly   101 SRIGDVPVEPQTWGIALKC-----SGT-----RNAEVTVTINVEV-ILDRATNN---------NT 145

Human   260 TAVV-------------------GSDVELLCKVYSDAQPHIQWL----KHIVINGSSFGADGFPY 301
            ..:.                   ..|::||..........|.::    :|:|.||........|.
  Fly   146 NLIFKRKKICLREEQDSAHEEYDDDDLDLLQTARKGHGGDIHYVDRNDEHVVANGHQAPEKQRPV 210

Human   302 VQVLKTADINSS----EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAA 362
            |........||.    :.:.:...|:....:|..|.:.|..:.|                     
  Fly   211 VTESPVGRGNSGGSKRDFDPMLRENLVPPASGLVTLIVGGILAL--------------------- 254

Human   363 PEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSS-- 425
                           :.::.|:|:|...:|.:  .|||.....:.|.|.|......|..:.:|  
  Fly   255 ---------------VLVSTLILIAYCAKGPS--KRHPSNGVHLIKTSSFQRLPTISSTAHNSIY 302

Human   426 ------GKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRD---------RLVLGKPLGE 475
                  ..:.::|.|..|.....|.                ||.|.         |:.|...:.|
  Fly   303 VCPSTITPTYATLTRPFREYEHEPE----------------EFNRRLQELTVQKCRVRLSCLVQE 351

Human   476 GCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVC 540
            |.||::.|...        :....|.||.:..:||...: :|:.:..:|.....|.|::::||:.
  Fly   352 GNFGRIYRGTY--------NDCQEVLVKTVAQHASQLQV-NLLLQESMMLYEASHPNVLSVLGIS 407

Human   541 TQE--GPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYL 603
            .::  .|..:.....:..||:.||:         .|...||    ::....|....|:|..|::|
  Fly   408 IEDYATPFVLYAATGSVRNLKSFLQ---------DPSYARS----VTTIQTVLMGSQLAMAMEHL 459

Human   604 ESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTH 668
            .:...||:|:||||.::.:...:|:.|..|:|.:...||.........|:||::.|||....|..
  Fly   460 HNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNE 524

Human   669 QSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQR 733
            .|||||||:|:||:.|||..||..|...|:...|::|:|:.:|.:||.||:.:|..||.:.|::|
  Fly   525 GSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAER 589

Human   734 PTFKQL 739
            |:|.||
  Fly   590 PSFSQL 595

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FGFR4NP_002002.3 Ig_3 36..104 CDD:464046
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 119..148
IgI_2_FGFR 147..241 CDD:409443 10/45 (22%)
Ig strand A 147..150 CDD:409443
Ig strand A' 158..163 CDD:409443
Ig strand B 167..175 CDD:409443
Ig strand C 181..186 CDD:409443
Ig strand C' 189..191 CDD:409443
Ig strand D 200..203 CDD:409443 0/2 (0%)
Ig strand E 207..212 CDD:409443 1/4 (25%)
Ig strand F 221..228 CDD:409443 1/6 (17%)
Ig strand G 231..241 CDD:409443 1/9 (11%)
Ig 249..351 CDD:472250 19/128 (15%)
Ig strand B 267..271 CDD:409444 1/3 (33%)
Ig strand C 280..284 CDD:409444 1/3 (33%)
Ig strand E 316..320 CDD:409444 0/3 (0%)
Ig strand F 330..335 CDD:409444 1/4 (25%)
Ig strand G 343..346 CDD:409444 0/2 (0%)
Protein Kinases, catalytic domain 454..767 CDD:473864 88/297 (30%)
drlNP_001260566.1 WIF 21..157 CDD:128745 14/75 (19%)
PTK_Ryk 336..606 CDD:270639 85/282 (30%)
Blue background indicates that the domain is not in the aligned region.

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