Protein Alignment FGFR4 and Ret

DIOPT Version :10

• Sequence 1: NP_002002.3
• Gene: FGFR4 / 2264
• HGNCID: 3691
• Length: 802
• Species: Homo sapiens
• Sequence 2: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Alignment Length: 382
• Identity: 161/382 - (42%)
• Similarity: 222/382 - (58%)
• Gaps: 35/382 - (9%)

Human   380 LAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPA 444
            |.|||||..|...:.:..|.      :.|.|....::|...|||....:...|..|.|..|.
  Fly   705 LFVLLLLCLLIAQRKMLQRR------LGKQSMTTSSKQALPESGGGDFALMPLQSGFRFESG--- 760

Human   445 LLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNA 509
                        |..|||||::|.|...||||.||||::  .|..:.|.....:||||||||..:
  Fly   761 ------------DAKWEFPREKLQLDTVLGEGEFGQVLK--GFATEIAGLPGITTVAVKMLKKGS 811

Human   510 SDKDLADLVSEMEVMKLIGRHKNIINLLGVCT-QEGPLYVIVECAAKGNLREFLRARRP---PGP 570
            :..:...|:||.::::.:. |.|:|.|||.|| .|.|| :|:|.|..|:||.:||..|.   .|.
  Fly   812 NSVEYMALLSEFQLLQEVS-HPNVIKLLGACTSSEAPL-LIIEYARYGSLRSYLRLSRKIECAGV 874

Human   571 DLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLAR 635
            |.: ||..    |::..::::.|:|:.:||.||...|.:||||||||||:.:..:.||:||||.|
  Fly   875 DFA-DGVE----PVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTR 934

Human   636 GVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFS 700
            .|:..|.|.|.|..|:||||||||:|.|.|||.:|||||||:|.||:.|||.||||||..:.|:|
  Fly   935 DVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWS 999

Human   701 LLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDL 757
            ||:.|:|||||.:|...:|.::|.||...|:.||:||.|....:| ||..:.:|:||
  Fly  1000 LLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEK-LLGNNAKYIDL 1055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGFR4	NP_002002.3	Ig_3	36..104	CDD:464046
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	119..148
		IgI_2_FGFR	147..241	CDD:409443
		Ig strand A	147..150	CDD:409443
		Ig strand A'	158..163	CDD:409443
		Ig strand B	167..175	CDD:409443
		Ig strand C	181..186	CDD:409443
		Ig strand C'	189..191	CDD:409443
		Ig strand D	200..203	CDD:409443
		Ig strand E	207..212	CDD:409443
		Ig strand F	221..228	CDD:409443
		Ig strand G	231..241	CDD:409443
		Ig	249..351	CDD:472250
		Ig strand B	267..271	CDD:409444
		Ig strand C	280..284	CDD:409444
		Ig strand E	316..320	CDD:409444
		Ig strand F	330..335	CDD:409444
		Ig strand G	343..346	CDD:409444
		Protein Kinases, catalytic domain	454..767	CDD:473864	143/308 (46%)
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	134/288 (47%)