Protein Alignment FGFR4 and Csk

DIOPT Version :10

• Sequence 1: NP_002002.3
• Gene: FGFR4 / 2264
• HGNCID: 3691
• Length: 802
• Species: Homo sapiens
• Sequence 2: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Alignment Length: 706
• Identity: 181/706 - (25%)
• Similarity: 288/706 - (40%)
• Gaps: 195/706 - (27%)

Human   137 SNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGI- 200
            |..|..|...|...|..| |..:|.:.||.......              ...|.:..|.|...
  Fly   427 SQPHIVPPSIPPHHHHHR-ENNVHPIQAGAAAALHL--------------SSHALNSHNLISSAS 476

Human   201 --------RLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPA 257
                    :.:.|..:...:......:.:::                 :|......|.:.|..||
  Fly   477 NHSPKSPSQTQQQQQTTNQQQQQQQQQASHS-----------------ILSTFAPAPTVAAVQPA 524

Human   258 NTTAVVGSDVELLCKVYSDAQPHIQWL-------------------------------KHIVING 291
            .:.:|.|:...:........|.|:|.|                               |.:.::|
  Fly   525 GSQSVAGTAAAVAAVAQQQQQQHLQLLANCPPGGAGLMSSSLNAAQMGMHGAERALPPKSLALSG 589

Human   292 SSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAE-DAGEYTCL---------AGNSIGLSYQSA 346
            |..|::     .:|.||.......:...:..||.. .||..|.|         ||:  |::..||
  Fly   590 SQHGSN-----MLLHTAPQPPQASQPAAVVGVSGSGSAGMSTSLHSFDINGVTAGS--GVNASSA 647

Human   347 W----LTVLPEEDPTWTAAAPEARYT--DIILYA----SGSLALAVLLLLAGLYRGQALHGRHPR 401
            |    .|.:.....:.||.||:...:  ::.|.|    .||:.           |.:|.|...||
  Fly   648 WSSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGSIT-----------RDEAEHLLQPR 701

Human   402 PPA--TVQKLSRFP--------------------LARQFSLESGSSGKSSSSLVRGVRLSSSGPA 444
            ...  .|::.:.||                    |..:.:::.....::...||......:.|
  Fly   702 EDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLENKLTIDDEEYFENLGQLVAHYEADADG-- 764

Human   445 LLAGLVSLDLP--------------LDPLWEFPRDRLVLGKPLGEGCFGQV----VRAEAFGMDP 491
            |...|:.. ||              :|..|..|...|.|.:.:|:|.||.|    :|.|
  Fly   765 LCTQLIKC-LPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNE------ 822

Human   492 ARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKG 556
                   .||||||||..:   :...::|..||..: .|.|::..:|:......||::.|..:||
  Fly   823 -------KVAVKMLKDEGA---VQKFLAEASVMTTL-EHDNLVKFIGLVFTSKHLYLVTEYMSKG 876

Human   557 NLREFLRARRPPGPDLSPDGPR--SSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVL 619
            :|.::||:|          |.:  :.:..:.|      ||..|.||:|||::|.:||||||||||
  Fly   877 SLVDYLRSR----------GRQHITKKDQIIF------AYDTASGMEYLEAKKVVHRDLAARNVL 925

Human   620 VTEDNVMKIADFGLAR-GVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIF 683
            ::||.|.|::|||||| ..:::|.      |:||:||.|||||.:..::::||:||||||||||:
  Fly   926 ISEDCVAKVSDFGLAREECYNLDV------GKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIY 984

Human   684 TLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQL 739
            :.|..|||.||:.::...:..|::|:.|..||||:|.:||:.|...|::||||.:|
  Fly   985 SFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL 1040

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGFR4	NP_002002.3	Ig_3	36..104	CDD:464046
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	119..148		3/10 (30%)
		IgI_2_FGFR	147..241	CDD:409443	11/102 (11%)
		Ig strand A	147..150	CDD:409443	1/2 (50%)
		Ig strand A'	158..163	CDD:409443	1/4 (25%)
		Ig strand B	167..175	CDD:409443	0/7 (0%)
		Ig strand C	181..186	CDD:409443	0/4 (0%)
		Ig strand C'	189..191	CDD:409443	0/1 (0%)
		Ig strand D	200..203	CDD:409443	0/11 (0%)
		Ig strand E	207..212	CDD:409443	0/4 (0%)
		Ig strand F	221..228	CDD:409443	0/6 (0%)
		Ig strand G	231..241	CDD:409443	0/9 (0%)
		Ig	249..351	CDD:472250	30/146 (21%)
		Ig strand B	267..271	CDD:409444	0/3 (0%)
		Ig strand C	280..284	CDD:409444	2/3 (67%)
		Ig strand E	316..320	CDD:409444	0/3 (0%)
		Ig strand F	330..335	CDD:409444	2/13 (15%)
		Ig strand G	343..346	CDD:409444	0/2 (0%)
		Protein Kinases, catalytic domain	454..767	CDD:473864	114/307 (37%)
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	19/110 (17%)
		PTKc_Csk_like	793..1047	CDD:270635	111/287 (39%)