DRSC/TRiP Functional Genomics Resources

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Protein Alignment FGFR4 and FER

DIOPT Version :10

Sequence 1:NP_002002.3 Gene:FGFR4 / 2264 HGNCID:3691 Length:802 Species:Homo sapiens
Sequence 2:NP_524288.3 Gene:FER / 41118 FlyBaseID:FBgn0000723 Length:1325 Species:Drosophila melanogaster


Alignment Length:358 Identity:117/358 - (32%)
Similarity:177/358 - (49%) Gaps:49/358 - (13%)


- Green bases have known domain annotations that are detailed below.


Human   398 RHPRPP-ATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWE 461
            |...|| |::|:|    :..|:..|...:.||.:.|.|.|                   ....||
  Fly  1016 RFEGPPFASIQEL----IMHQYHSELPVTVKSGAILRRPV-------------------CRERWE 1057

Human   462 FPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKL 526
            ...|.:||.:.:|.|.||.|.:|:   :...:.|    ||||..:....|:.....:.|..::|.
  Fly  1058 LSNDDVVLLERIGRGNFGDVYKAK---LKSTKLD----VAVKTCRMTLPDEQKRKFLQEGRILKQ 1115

Human   527 IGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVS 591
            .. |.||:.|:|:|.|:.|:.:::|....|:|..:||              ::|.|..:...:..
  Fly  1116 YD-HPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLR--------------KNSNGLTTRQQMGM 1165

Human   592 CAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWM 656
            |. ..|.||:||||:.||||||||||.||..::.:||:|||::|  ...:|.......::||||.
  Fly  1166 CR-DAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWT 1227

Human   657 APEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGL 721
            |||||....||...||||:|||:||||:.|.:||.|:........:..|:||..|...|.|:|.|
  Fly  1228 APEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRL 1292

Human   722 MRECWHAAPSQRPTFKQLVEALDKVLLAVSEEY 754
            |.:||.|....||.|.::...:|.::|.:...:
  Fly  1293 MLQCWAADAESRPHFDEIYNVVDALILRLDNSH 1325

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FGFR4NP_002002.3 Ig_3 36..104 CDD:464046
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 119..148
IgI_2_FGFR 147..241 CDD:409443
Ig strand A 147..150 CDD:409443
Ig strand A' 158..163 CDD:409443
Ig strand B 167..175 CDD:409443
Ig strand C 181..186 CDD:409443
Ig strand C' 189..191 CDD:409443
Ig strand D 200..203 CDD:409443
Ig strand E 207..212 CDD:409443
Ig strand F 221..228 CDD:409443
Ig strand G 231..241 CDD:409443
Ig 249..351 CDD:472250
Ig strand B 267..271 CDD:409444
Ig strand C 280..284 CDD:409444
Ig strand E 316..320 CDD:409444
Ig strand F 330..335 CDD:409444
Ig strand G 343..346 CDD:409444
Protein Kinases, catalytic domain 454..767 CDD:473864 104/301 (35%)
FERNP_524288.3 F-BAR_Fes_Fer 7..243 CDD:153341
SH2_Fps_family 953..1039 CDD:198224 8/26 (31%)
PTKc_Fes_like 1067..1315 CDD:270637 97/272 (36%)
Blue background indicates that the domain is not in the aligned region.

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