DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FGFR4 and btl

DIOPT Version :10

Sequence 1:NP_002002.3 Gene:FGFR4 / 2264 HGNCID:3691 Length:802 Species:Homo sapiens
Sequence 2:NP_729956.1 Gene:btl / 39564 FlyBaseID:FBgn0285896 Length:1052 Species:Drosophila melanogaster


Alignment Length:857 Identity:308/857 - (35%)
Similarity:423/857 - (49%) Gaps:132/857 - (15%)


- Green bases have known domain annotations that are detailed below.


Human    22 LEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCC----GRAERGGHWYKEGSRLAPAGRVRGW 82
            ||........|.|.|.   ..:..::|||..|.:.|    ...|....|..:|:    |..:...
  Fly   230 LEVISRKHTVPMLKPG---YPRNTSIALGDNVSIECLLEDSALEPKITWLHKGN----ADNIDDL 287

Human    83 RGRLEIASFLP-----------------------EDAGRYLCLARGSM----------------- 107
            ..||...|.||                       ||.|.|:|:|...:                 
  Fly   288 LQRLREQSQLPVDVTRLITRMDEPQVLRLGNVLMEDGGWYICIAENQVGRTVAASYVDLYSPSDT 352

Human   108 --IVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRME-KKLHAVPAGNTVK 169
              :.....|.:.....|:|..:::.....:|:...|.....|.:    |.| |:|....:||||.
  Fly   353 TTVRTTTTTTVASPIPTASTGEDNDDDVENPAAEASGGVGPPVF----RKELKRLQHSLSGNTVN 413

Human   170 FRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIR 234
            ..||..|.  ..|.|.||.:..   ||..|:.:: ::|:|........|.|.|.|.|.||.|.|:
  Fly   414 LACPVYGK--ANITWTKDKKPL---NRELGVYVQ-KNWTLRFVEATSEDSGLYNCKVCNAWGCIQ 472

Human   235 YNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGF 299
            :::.:.:.:|:...||:.  :|.|.|..|...:.:.|.||||..|.:.| |.:|:..:|.  ||.
  Fly   473 FDFSVQINDRTRSAPIIV--VPQNQTVKVNGSLVMKCTVYSDLHPTVSW-KRVVLKNASL--DGL 532

Human   300 PYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPT------- 357
            ..|::.......:::..||.||||:.:..|.|||||.:.:|.|..|.:|.|:....|.       
  Fly   533 KSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVVSPLPPLEIYALLH 597

Human   358 -----WTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQ 417
                 :|.||    .|.:.|:..||  ..:..:|..|.|.:.|..|    ..||.:.::..:..:
  Fly   598 AHPLGFTLAA----ITIVALFLLGS--AFITFMLRRLRREKLLKLR----IETVHQWTKKVIIYR 652

Human   418 FSLESGSSGKSSSSLVRGV--------RLSSSG-----PALLAGLVSLDLPLDPLWEFPRDRLVL 469
            ...|.| ||.||..|...|        .:|::|     ||  .|....:.|||..||.||.:|.|
  Fly   653 PGGEEG-SGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPA--QGFNEYEFPLDSNWEIPRQQLSL 714

Human   470 GKPLGEGCFGQVVRAEAFGMDPARPDQAST-VAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNI 533
            |..||||.||:||.|||.|: |..|..|.| |||||:|:..:|.|:|.||.||||||:||:|.||
  Fly   715 GSILGEGAFGRVVMAEAEGL-PRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINI 778

Human   534 INLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSC------ 592
            |||||.|:|.|||:||||.|..|||::||:..||..|....|    |:|.|....|:|.      
  Fly   779 INLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSD----SDGYLDDKPLISTQHLGEK 839

Human   593 -----AYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLP 652
                 |:|:||||:||.||:|||||||||||||::..|||||||||||.:...:||:|.:|||||
  Fly   840 ELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLP 904

Human   653 VKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGI-PVEELFSLLREGHRMDRPPHCPP 716
            :||||||:|.::.|..||||||:|:|||||.|.|..|||.| ..|||:|.|..|.||::|..|..
  Fly   905 IKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSL 969

Human   717 ELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVS----EEYLDLRLTFGPYSPSGGDASSTCSS 777
            .:|.:||:|||.....||||.:|||:.|.:|...|    :.||||.:......||.||..   ..
  Fly   970 NIYVVMRQCWHFESCARPTFAELVESFDGILQQASSNPNDAYLDLSMPMLETPPSSGDED---DG 1031

Human   778 SDSVFSHDPLPL 789
            ||:....:..||
  Fly  1032 SDTETFRETSPL 1043

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FGFR4NP_002002.3 Ig_3 36..104 CDD:464046 20/94 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 119..148 4/28 (14%)
IgI_2_FGFR 147..241 CDD:409443 30/94 (32%)
Ig strand A 147..150 CDD:409443 1/2 (50%)
Ig strand A' 158..163 CDD:409443 1/4 (25%)
Ig strand B 167..175 CDD:409443 4/7 (57%)
Ig strand C 181..186 CDD:409443 2/4 (50%)
Ig strand C' 189..191 CDD:409443 0/1 (0%)
Ig strand D 200..203 CDD:409443 0/2 (0%)
Ig strand E 207..212 CDD:409443 2/4 (50%)
Ig strand F 221..228 CDD:409443 3/6 (50%)
Ig strand G 231..241 CDD:409443 2/9 (22%)
Ig 249..351 CDD:472250 35/101 (35%)
Ig strand B 267..271 CDD:409444 0/3 (0%)
Ig strand C 280..284 CDD:409444 0/3 (0%)
Ig strand E 316..320 CDD:409444 2/3 (67%)
Ig strand F 330..335 CDD:409444 3/4 (75%)
Ig strand G 343..346 CDD:409444 0/2 (0%)
Protein Kinases, catalytic domain 454..767 CDD:473864 175/329 (53%)
btlNP_729956.1 Ig 143..215 CDD:472250
Ig strand B 160..164 CDD:409570
Ig strand C 175..179 CDD:409570
Ig strand E 197..201 CDD:409570
Ig strand F 211..215 CDD:409570
Ig_3 247..333 CDD:464046 20/89 (22%)
Ig 398..479 CDD:472250 28/86 (33%)
Ig strand B 412..416 CDD:409393 1/3 (33%)
Ig strand C 423..427 CDD:409393 1/3 (33%)
Ig strand E 445..449 CDD:409393 2/3 (67%)
Ig strand F 459..464 CDD:409393 2/4 (50%)
Ig strand G 472..475 CDD:409393 0/2 (0%)
IG_like 492..583 CDD:214653 33/93 (35%)
Ig strand B 503..507 CDD:409444 0/3 (0%)
Ig strand C 516..520 CDD:409444 1/4 (25%)
Ig strand E 549..553 CDD:409444 2/3 (67%)
Ig strand F 563..568 CDD:409444 3/4 (75%)
Ig strand G 576..579 CDD:409444 0/2 (0%)
Protein Kinases, catalytic domain 700..1000 CDD:473864 169/304 (56%)
Blue background indicates that the domain is not in the aligned region.

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