DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FGFR4 and drpr

DIOPT Version :9

Sequence 1:	NP_001341913.1	Gene:	FGFR4 / 2264	HGNCID:	3691	Length:	802	Species:	Homo sapiens
Sequence 2:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster

Alignment Length:	198	Identity:	35/198 - (17%)
Similarity:	68/198 - (34%)	Gaps:	57/198 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   194 ENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPAN 258
            |.|:....:|.:..:....|.:.:|.|. .|.....|||...||..|:|.::         |.|:
  Fly   863 ETRLLPNNMRSKMNNFDQRSTMSTDYGD-DCNASGRVGSYSINYNHDLLTKN---------LNAD 917

Human   259 TTAVVGSDVELLCKVYSDA--QPHI-QWLKH--------IVINGSSFGADGFPYVQVLKTA---- 308
            .|..:         ||:::  :.|: ..:||        .:.:...|..|.:.::...:.:
  Fly   918 RTNPI---------VYNESLKEEHVYDEIKHKEGYKDPVKIYSKILFPEDEYDHLDYSRPSTSQK 973

Human   309 -----------DINSSEVEVLYLRNVS---------AEDAGEYTCLAGNSIGLSYQSAWLTVLPE 353
                       :||..|.:...::|::         .|...::.|....:..|...|   |..|.
  Fly   974 PHYHRMNDAMLNINQDEEKPSNVKNMTVLLNKPLPPTEPEPQHECFDNTNTNLDNVS---TASPS 1035

Human   354 EDP 356
            ..|
  Fly  1036 SSP 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FGFR4	NP_001341913.1	IGc2	50..107	CDD:197706
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..148
		Ig	157..241	CDD:325142	12/46 (26%)
		Ig3_FGFR-2	264..351	CDD:143266	16/121 (13%)
		PKc_like	454..767	CDD:328722
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395
		DSL	<479..518	CDD:302925
		DSL	<567..606	CDD:302925
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900