DRSC/TRiP Functional Genomics Resources

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Protein Alignment FGFR4 and Src42A

DIOPT Version :10

Sequence 1:NP_002002.3 Gene:FGFR4 / 2264 HGNCID:3691 Length:802 Species:Homo sapiens
Sequence 2:NP_001400996.1 Gene:Src42A / 35524 FlyBaseID:FBgn0264959 Length:1606 Species:Drosophila melanogaster


Alignment Length:295 Identity:124/295 - (42%)
Similarity:163/295 - (55%) Gaps:24/295 - (8%)


- Green bases have known domain annotations that are detailed below.


Human   460 WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVM 524
            ||..|..|...:.||.|.||.|.........|        ||:|.||....|.  .|.::|.::|
  Fly  1330 WEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTP--------VAIKTLKSGTMDP--KDFLAEAQIM 1384

Human   525 KLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVL 589
            |.: ||..:|.|..|||.|.|:|:|.|....|:|.|:|:|....|        ||    |....|
  Fly  1385 KKL-RHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKG--------RS----LKMQTL 1436

Human   590 VSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVK 654
            :..|.|:|.||.||||:..||||||||||||.:.|::|||||||||.:.. |.|:.....|.|:|
  Fly  1437 IDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKE-DEYEARVGARFPIK 1500

Human   655 WMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELY 719
            |.||||.....::.:||||||||||.|:.|.|..||||:...|:.:.:..|:||.:||:|.|.||
  Fly  1501 WTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLY 1565

Human   720 GLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEY 754
            .:|.||||..|.:||||:.|...|:....:...:|
  Fly  1566 EIMLECWHKDPMRRPTFETLQWKLEDFYTSDQSDY 1600

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FGFR4NP_002002.3 Ig_3 36..104 CDD:464046
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 119..148
IgI_2_FGFR 147..241 CDD:409443
Ig strand A 147..150 CDD:409443
Ig strand A' 158..163 CDD:409443
Ig strand B 167..175 CDD:409443
Ig strand C 181..186 CDD:409443
Ig strand C' 189..191 CDD:409443
Ig strand D 200..203 CDD:409443
Ig strand E 207..212 CDD:409443
Ig strand F 221..228 CDD:409443
Ig strand G 231..241 CDD:409443
Ig 249..351 CDD:472250
Ig strand B 267..271 CDD:409444
Ig strand C 280..284 CDD:409444
Ig strand E 316..320 CDD:409444
Ig strand F 330..335 CDD:409444
Ig strand G 343..346 CDD:409444
Protein Kinases, catalytic domain 454..767 CDD:473864 124/295 (42%)
Src42ANP_001400996.1 SH2_Src_Src42 1210..1301 CDD:198233
PTKc_Frk_like 1328..1596 CDD:270653 123/289 (43%)
Blue background indicates that the domain is not in the aligned region.

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