DRSC/TRiP Functional Genomics Resources

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Protein Alignment FGFR4 and dnt

DIOPT Version :10

Sequence 1:NP_002002.3 Gene:FGFR4 / 2264 HGNCID:3691 Length:802 Species:Homo sapiens
Sequence 2:NP_477341.2 Gene:dnt / 35207 FlyBaseID:FBgn0024245 Length:584 Species:Drosophila melanogaster


Alignment Length:571 Identity:152/571 - (26%)
Similarity:242/571 - (42%) Gaps:132/571 - (23%)


- Green bases have known domain annotations that are detailed below.


Human   236 NYLLDVLERSP---------HRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVING 291
            ||.|:.:...|         .:.:...|||.:.. ||.||.|:|      .:|        .||.
  Fly    76 NYALNFIVPVPANVKDISFTWQSLAGRGLPYSIN-VVSSDQEVL------PRP--------AINV 125

Human   292 SSFGADGFP-----YVQVLKTADINSSEVEV------------------------LYLRNVSAED 327
            |..|.  .|     :...||.:.:.::||:|                        :.|.|.||||
  Fly   126 SHSGE--IPTTIQTWSIALKCSGLKAAEVDVTVSLEVVLNRSLNNVTHLVFRRKKICLMNDSAED 188

Human   328 AGEYTCLAGNSIGLSYQSAWLTVLPEEDPTW--TAAAPEARYTDIIL---YASGSLALAVLLLLA 387
            ..|                     ..:||..  |...|......:::   .|.||:.|  ||::|
  Fly   189 LSE---------------------DVDDPQLLETVMLPPTGLITLVVGVSVAMGSVCL--LLMIA 230

Human   388 GLYRGQA------LHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSS-------SSLVRGVRLS 439
            ...:|.|      .||..|...::.|:|:..|.. |.|:.|.:....|       |||.|.|.:|
  Fly   231 YCVKGAANKRQHHQHGGQPMRTSSFQRLNTHPPC-QSSMGSAAYMTPSIIAPIHGSSLPRKVPVS 294

Human   440 --SSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAV 502
              ...|..|...:| :|.::      |.|:.|...|.||.||:|.|...        :....|.|
  Fly   295 VEQQHPEELHRRIS-ELTVE------RCRVRLSSLLQEGTFGRVYRGTY--------NDTQDVLV 344

Human   503 KMLKDNASDKDLADLVSEMEVMKLIG-RHKNIINLLGVCTQEGPLYVIVECAAKG--NLREFLRA 564
            |.:..:||...:  |:...|.|.|.| .|..|:::|||..::.....::..|...  ||::||  
  Fly   345 KTVAQHASQMQV--LLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNTRNLKQFL-- 405

Human   565 RRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIA 629
                   |.|...|:    ::...:|..|.|::..:.:|.|...:|:|:|.||.::.:...:|::
  Fly   406 -------LDPACART----VTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLS 459

Human   630 DFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIP 694
            |..|:|.:...||.....:...|||||:.|||..:.::..||.|:||:|:||:.|....||..:.
  Fly   460 DSSLSRDLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVD 524

Human   695 VEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDK 745
            ..|:...|::|:|:.:|.:||.||:.:|..||...|::||||.||...|.:
  Fly   525 PFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQSCLSE 575

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FGFR4NP_002002.3 Ig_3 36..104 CDD:464046
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 119..148
IgI_2_FGFR 147..241 CDD:409443 3/4 (75%)
Ig strand A 147..150 CDD:409443
Ig strand A' 158..163 CDD:409443
Ig strand B 167..175 CDD:409443
Ig strand C 181..186 CDD:409443
Ig strand C' 189..191 CDD:409443
Ig strand D 200..203 CDD:409443
Ig strand E 207..212 CDD:409443
Ig strand F 221..228 CDD:409443
Ig strand G 231..241 CDD:409443 3/4 (75%)
Ig 249..351 CDD:472250 27/130 (21%)
Ig strand B 267..271 CDD:409444 1/3 (33%)
Ig strand C 280..284 CDD:409444 0/3 (0%)
Ig strand E 316..320 CDD:409444 1/27 (4%)
Ig strand F 330..335 CDD:409444 1/4 (25%)
Ig strand G 343..346 CDD:409444 0/2 (0%)
Protein Kinases, catalytic domain 454..767 CDD:473864 89/295 (30%)
dntNP_477341.2 WIF 46..182 CDD:128745 24/122 (20%)
Protein Kinases, catalytic domain 310..580 CDD:473864 89/295 (30%)
Blue background indicates that the domain is not in the aligned region.

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