Protein Alignment FGFR4 and CG3277

DIOPT Version :10

• Sequence 1: NP_002002.3
• Gene: FGFR4 / 2264
• HGNCID: 3691
• Length: 802
• Species: Homo sapiens
• Sequence 2: NP_608762.3
• Gene: CG3277 / 33543
• FlyBaseID: FBgn0031518
• Length: 789
• Species: Drosophila melanogaster
• Alignment Length: 657
• Identity: 180/657 - (27%)
• Similarity: 287/657 - (43%)
• Gaps: 154/657 - (23%)

Human   222 YTCLVENAVGSIRYN---YLLDVLE--------RSPHRPILQAGLPANTTAVVGSDV---ELL-- 270
            |..:||.:...:|.:   |:...||        .:|.:.:..|.:.:|.|..:...:   |||
  Fly   170 YQVIVETSNAMVRRSARVYIPQCLEGKCSCQLAPTPPKVLAVAKMLSNETISINLSILASELLRK 234

Human   271 ----------------CKVYSDAQPHIQW---LKHIV-----INGSSFGADGFPYVQVLKTA-DI 310
                            .|:..:..|.:.|   |||::     ::..:|.|....:..|:|.. ..
  Fly   235 EQDSHLHETLRTYKMQLKINEETNPSLPWGGVLKHLMTRVYKLSELNFRATPKGFEGVMKLGLGT 299

Human   311 NSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYAS 375
            ...|...|.|:.|..:..|   |....|:......|...:|.|.|..          ::.|:..|
  Fly   300 QLKEKASLSLQAVIIDPTG---CEGPRSVTKVPVPANPVLLTEGDSV----------SNSIIVMS 351

Human   376 GSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSS 440
               |:.:.::||||.. ..|..|..|..|.::|..:..: :.|:..:.....:.:.:.:.|..|.
  Fly   352 ---AMLIAIILAGLIM-LLLRRRRARTTAKLRKQEQIYI-QTFATSAIEMEDNVNYVDKYVEKSQ 411

Human   441 SGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKML 505
            .            |.|..::|.|...:.:|:.||||.||||..|.|..:  .|....:.||||.|
  Fly   412 V------------LGLADIFEVPHSAIQIGRMLGEGAFGQVHEATAINL--RRMRGTTIVAVKQL 462

Human   506 KDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGP 570
            |.|....::|:.::|:|::|.:|.|.|:::.||.||.:.|..:|:|...||||..:||..|....
  Fly   463 KPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSYLRTVRKEAS 527

Human   571 DL------------------SPDGPRS----------SEGPLSFP-------------------- 587
            .|                  |...|:|          |...:..|
  Fly   528 KLRNRNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQPHPSFAE 592

Human   588 -------------------VLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGL 633
                               .|.:.|.|:|.||::||.::..||||||||||:..:..:||:||||
  Fly   593 TTYTIVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGL 657

Human   634 ARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEEL 698
            :|  |.|  |..|...:||::|::.||:.:.||:.:||:|::|::||||.|||.||||.|..:||
  Fly   658 SR--HGI--YTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTISNDEL 718

Human   699 FSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLR----- 758
            ...|..|:|::||..|.|::|.:|.:||...|.:||||    :||.|| |:....|:|:.
  Fly   719 IPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTF----DALYKV-LSPKTTYVDINSLSDD 778

Human   759 LTFGPYS 765
            ..|.|.|
  Fly   779 YVFPPIS 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGFR4	NP_002002.3	Ig_3	36..104	CDD:464046
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	119..148
		IgI_2_FGFR	147..241	CDD:409443	5/21 (24%)
		Ig strand A	147..150	CDD:409443
		Ig strand A'	158..163	CDD:409443
		Ig strand B	167..175	CDD:409443
		Ig strand C	181..186	CDD:409443
		Ig strand C'	189..191	CDD:409443
		Ig strand D	200..203	CDD:409443
		Ig strand E	207..212	CDD:409443
		Ig strand F	221..228	CDD:409443	2/5 (40%)
		Ig strand G	231..241	CDD:409443	2/12 (17%)
		Ig	249..351	CDD:472250	24/131 (18%)
		Ig strand B	267..271	CDD:409444	3/24 (13%)
		Ig strand C	280..284	CDD:409444	1/6 (17%)
		Ig strand E	316..320	CDD:409444	1/3 (33%)
		Ig strand F	330..335	CDD:409444	1/4 (25%)
		Ig strand G	343..346	CDD:409444	0/2 (0%)
		Protein Kinases, catalytic domain	454..767	CDD:473864	130/384 (34%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	119/343 (35%)