DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FGFR2 and Cad96Ca

DIOPT Version :9

Sequence 1:	XP_006717771.1	Gene:	FGFR2 / 2263	HGNCID:	3689	Length:	839	Species:	Homo sapiens
Sequence 2:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster

Alignment Length:	830	Identity:	226/830 - (27%)
Similarity:	348/830 - (41%)	Gaps:	233/830 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    42 PSFSLV--EDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRT 104
            |.|||.  |:....||:.|  :||.: |..|....|||..|........|:.| ||.:...|...
  Fly    95 PRFSLPGGENDASPPEKIP--FQIDR-ETGVVTLNESLAGRAGQNFLIYITVT-DGSYTAKNEVF 155

Human   105 V-LIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSN 168
            : ::||.....|..|:.|                  :.||...||......|.......:.....
  Fly   156 INILGERENSSGYRPQTS------------------ISNVVHNISQFLPRFDQLPGVQSIRNGLP 202

Human   169 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGN-------PMPTMRWLKNGKEFKQEHRIGGY 226
            |.|...|         ...||..|.  |..|..||       .:|.:|..::|:|.:.:..:
  Fly   203 NSRPGGW---------YPPVPQNNI--FGPPPFGNNYPPPPPNIPGVRGEQSGEEEQPDEEV--- 253

Human   227 KVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGG 291
               .....:.:.|..|..:...|.:..|     |.|.             :::.:||..:|..||
  Fly   254 ---TPTTPVRISSTTPKSRTKLTPITAN-----NSTR-------------VESAIPAETTTPSGG 297

Human   292 DVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGE 356
                                                     |...:||...:.:|.:.|
  Fly   298 -----------------------------------------HHNNSSSPITIFSLKSGT------ 315

Human   357 YICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCR-- 419
                                :|                    .:..:|.|.:|..|:...|||
  Fly   316 --------------------IP--------------------IVVTVGGFFVAIAVLLAYLCRRR 340

Human   420 -------MKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSM------------NSNTPLVR- 464
                   :|.|.:|.:.:      |.:.:..|...::.:|.:||            |...|..|
  Fly   341 LCAISRTLKKTKEKEELA------KKSNQSQLSSTLTDDSRNSMVMQQWQGPVAFANRYVPWERD 399

Human   465 -----ITTRLS--------STADTP---------------MLAGVSEYELPED--------PKWE 493
                 .|::||        |:...|               :..|......||:        .:||
  Fly   400 QQMGIATSQLSTGVTNGGVSSPGVPSPGTGEPGSNLGPGCLTGGAGSSGAPENAFAGEANCDRWE 464

Human   494 FPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM 558
            |||.:|.....||||.||||...||..|:.:  :...|||||.||:.|||.|..||:||:|:||.
  Fly   465 FPRYRLKFFNILGEGAFGQVWRCEATNINGN--EGITTVAVKTLKESATEVDRKDLLSELEVMKS 527

Human   559 IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVS 623
            :..|.|:::|||.||...|.:||:||.::|.|:.|||:.|   .|..|.........:|..||.|
  Fly   528 LEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSR---AERHYGNTHGKSNVLTSCDLTS 589

Human   624 CTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWM 688
            ..||:|:||:||.|:..|||||||||:|:|:::..|:||||.|||:.....|::.:.|:||::||
  Fly   590 FMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWM 654

Human   689 APEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMM 753
            |.|:|:|.:::.:||:||||:|||||.|||.:|||||...::.:.:::|:|::||.:|..|||.:
  Fly   655 ATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELYNI 719

Human   754 MRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPD 803
            |..||...|.:||.|.::::.||::  |.|..:|::|.:        :||
  Fly   720 MYYCWSHDPQERPLFAEIIQMLDKL--LHTEMDYIELER--------FPD 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FGFR2	XP_006717771.1	Ig1_FGFR	66..143	CDD:143174	16/77 (21%)
		IG_like	66..143	CDD:214653	16/77 (21%)
		Ig2_FGFR	183..267	CDD:143265	17/90 (19%)
		IG_like	282..376	CDD:214653	10/93 (11%)
		Ig3_FGFR	290..377	CDD:143175	7/86 (8%)
		PTKc_FGFR2	474..786	CDD:270679	138/334 (41%)
		Pkinase_Tyr	499..775	CDD:285015	125/275 (45%)
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	23/72 (32%)
		STYKc	470..741	CDD:214568	125/275 (45%)
		PTKc	474..742	CDD:270623	124/272 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.770