Protein Alignment FGFR2 and tor

DIOPT Version :9

• Sequence 1: XP_006717771.1
• Gene: FGFR2 / 2263
• HGNCID: 3689
• Length: 839
• Species: Homo sapiens
• Sequence 2: NP_476762.1
• Gene: tor / 35717
• FlyBaseID: FBgn0003733
• Length: 923
• Species: Drosophila melanogaster
• Alignment Length: 820
• Identity: 198/820 - (24%)
• Similarity: 323/820 - (39%)
• Gaps: 292/820 - (35%)

Human   174 YWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIME 238
            |.||:..|::.|.       |:||     :.....|...:..||.:::.:|   ||..:....:|
  Fly   218 YSTNSVNMDEPLE-------VQFR-----DRKKLYRHTVDNLEFDKQYHVG---VRTVNIMNRLE 267

Human   239 S-------VVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRP----ILQAGLPANASTVVGGD 292
            |       .|||      |:   ::...|:|.      ..||:|    :.|.....|...:
  Fly   268 SDLQWLPIAVPS------CL---DWYPYNYTL------CPPHKPENLTVTQKQYLPNILAL---- 313

Human   293 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNV----TEAD 353
                         :|.|.:      .:|.||..                 .|.:|::    ||.
  Fly   314 -------------NITWAR------PRYLPDNY-----------------TLHIFDLFKGGTEL- 341

Human   354 AGEYICKVSNYIGQANQSAW----LTVLPK--------QQAPGREKE-----------ITASPDY 395
                     ||....|:|.:    :|||..        |.|.|:...           :.:..:.
  Fly   342 ---------NYTLDQNRSHFYVPKITVLGSHFEVHLVAQSAGGKNVSGLTLDKVHRGVLLSEGNM 397

Human   396 LEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNT 460
            :::.::.|.......|:.::..|| :|.::         |..|        |:.|:.:.:...:.
  Fly   398 VKLVLFIIVPICCILMLCSLTFCR-RNRSE---------VQAL--------QMDAKDAKASEFHL 444

Human   461 PLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 525
            .|:..:..|.:.:....|..:.|.|:  :|      ..:.|...||||.||.|    ..|:.|.:
  Fly   445 SLMDSSGLLVTLSANESLEVMDELEV--EP------HSVLLQDVLGEGAFGLV----RRGVYKKR 497

Human   526 PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQ-DGPLYVIVEYASKGN 589
                 .||||:|||:..::|:.....|::|:|.:|||.||:.::|..|: ...:.:::||.|.|:
  Fly   498 -----QVAVKLLKDEPNDEDVYAFKCEIQMLKAVGKHPNIVGIVGYSTRFSNQMMLLIEYCSLGS 557

Human   590 LREYLRAR-----------RPPGMEYSYD---INRVP-------------------EEQ------ 615
            |:.:||..           ....:|.:.|   .||:|                   ||:
  Fly   558 LQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRFNRLPRNSIHDRIEDINNSMLSTVEEESESDQT 622

Human   616 ----------------------------------------------------------------- 615
                                                                             
  Fly   623 HSSRCETYTLTRITNAADNKGYGLEDIENIGGSYIPKTAEAPKDRPKRKLKPQPKKDSKQDFKSD 687

Human   616 -------------------------MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTEN 655
                                     :.:.||:....|:|.|||:||..|.:||||||||||::.:
  Fly   688 NKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDIAQQVAVGMEFLAQNKVVHRDLAARNVLISVD 752

Human   656 NVMKIADFGLARDINNIDYYKKT-TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGG 719
            ..:|||||||:||:.:.:.|:|: .:|:||:||:|.|:|..:|||.||||||||||::||.||||
  Fly   753 RSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWLALESLTHQVYTSQSDVWSFGVLLYEITTLGG 817

Human   720 SPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTN 784
            .|||.:...:|.:||::||||.:|..||.|::.:|..||.:|||.||||..|...|..:: |.||
  Fly   818 MPYPSVSPSDLLQLLRQGHRMKRPEGCTQEMFSLMESCWSSVPSHRPTFSALKHRLGGMI-LATN 881

Human   785 EEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYE 824
                |:.:.|:|...:......||...:..|   :.:|.|
  Fly   882 ----DVPERLKQLQAATESKLKSCDGLNSKV---EQVPCE 914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGFR2	XP_006717771.1	Ig1_FGFR	66..143	CDD:143174
		IG_like	66..143	CDD:214653
		Ig2_FGFR	183..267	CDD:143265	18/90 (20%)
		IG_like	282..376	CDD:214653	14/101 (14%)
		Ig3_FGFR	290..377	CDD:143175	14/94 (15%)
		PTKc_FGFR2	474..786	CDD:270679	133/442 (30%)
		Pkinase_Tyr	499..775	CDD:285015	125/406 (31%)
tor	NP_476762.1	FN3	199..261	CDD:214495	14/57 (25%)
		STYKc	475..873	CDD:214568	125/406 (31%)
		PTKc	479..873	CDD:270623	124/402 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910