Protein Alignment GPC5 and dlp

DIOPT Version :10

• Sequence 1: NP_004457.1
• Gene: GPC5 / 2262
• HGNCID: 4453
• Length: 572
• Species: Homo sapiens
• Sequence 2: NP_524071.2
• Gene: dlp / 39596
• FlyBaseID: FBgn0041604
• Length: 765
• Species: Drosophila melanogaster
• Alignment Length: 681
• Identity: 156/681 - (22%)
• Similarity: 277/681 - (40%)
• Gaps: 150/681 - (22%)

Human    30 CEEVRKLFQWRLLGAVRGLPDSPRAGPDLQVCISKK-PTCCTRKMEERYQIAARQDMQQFLQTSS 93
            |..|..:||.|.:.|:. :|..|.....|:.|.|.. .||||..||.|..:.:||.::...:...
  Fly    80 CSAVTHIFQARGIDAIE-IPQKPSNERVLRYCESPSVGTCCTYNMETRMAMQSRQQLEGHTKDQI 143

Human    94 STLKFLISRNAAAFQETLETLIKQAENYTSILFCSTYRNMALEAAASVQEFFTDVGLYLFGADVN 158
            |.:..::...|..|::....|:|::....:.:|..||..:....:....:.|.::..|.....|:
  Fly   144 SRMSGILGSKATKFKDIFTALLKESRTQFNSMFIRTYGVIYERNSYVFSDLFKELETYFANGRVD 208

Human   159 PEEFVNRFFDSLFPLVYNHLINPGVTDSSLEYSECIRMARRDVSPFGNIPQRVMGQMGRSLLPSR 223
            ..|.:::||::|:..::..|......|.:  |..|:....:::.|||::|.::..|:.||.:.:|
  Fly   209 LLEVMDKFFNTLYQKMFTVLNTQYTFDEN--YMRCVSEHMKELKPFGDVPDKLSVQIKRSFVATR 271

Human   224 TFLQALNLGIEVINTTDYLHFSKECSRALLKMQYCPHCQGLALTKPCMGYCLNVMRGCLAHMAEL 288
            |:.|||....||......:..:.:|:.||.|||:|..|:|.. .|||..||:||::|||.:..|.
  Fly   272 TYGQALTTASEVAKKVLNVRLNADCTGALTKMQHCGACKGYT-EKPCTNYCVNVIKGCLHYQHEF 335

Human   289 NPHWHAYIRSLEELSDAMHGTYDIGHVLLNFHLLVNDAVLQAHLNGQKLLEQVNRICGRP----- 348
            :..|..:..:::::::.:.|:::|..|:...::.:::|::....:||.:..:|.:.||||
  Fly   336 DSEWENFAMAMDKVAERLLGSFNIVMVVEPLNIKISEAIMNFQDSGQDITNRVFQGCGRPKLKKM 400

Human   349 ---------------VRTPTQSPRCSFDQ------------SKEKHGMKTTTRNSEETLA----- 381
                           .|:|.::.....|:            :.|....:|:.:.|:|...
  Fly   401 KRSISPKLQGVQILNARSPVEADTLDIDETLDEAIVLRERRAAEPGSQETSAQQSQEQGVGKSGN 465

Human   382 --------NRRKE------------------------------------FINSLRL----YRSFY 398
                    |||::                                    .:..:|.    |:.|:
  Fly   466 GGGGGGGNNRRQQQRRKQQQQRRKQQNNRDDNDDDDNESGGGREPILDRIVRDIRQRVKDYKKFW 530

Human   399 GGLADQLCANELAAA----DGLPCWNGEDIVKSYTQRVVGNGIKAQ-SGNPEVKVKGIDPVINQI 458
            ..|...:|:||..|:    ||: ||||..|.:........:|...: :||| ...|....:.:|:
  Fly   531 SNLPHSVCSNEDIASSSDVDGM-CWNGHTIDRYMHSITTEHGSNPEFTGNP-ASTKQTAQMASQL 593

Human   459 IDKLKHVVQLLQGRSPKPDKW----ELLQLGSGGGMVEQVSGDCDDEDGCGGSGSG--------E 511
            ......:|.|....:.:..:|    ||...|||.|   ..||..||||...|||.|        :
  Fly   594 SHLKNAIVHLRNAYNGQDVEWSEQEELPYAGSGAG---SGSGSEDDEDDDEGSGLGPFEPSHKPD 655

Human   512 VKR----------------------TLKITDWMPD----------DMNFSDVKQIH-QTDTGSTL 543
            |:|                      |.:.|..:.|          |.:.:|:.:.| |.|.....
  Fly   656 VERPSVDADNDDDEDAGGRGHMPTHTSRPTSGVDDKNPLIHTTHFDQDHNDLDEDHRQLDEDEDT 720

Human   544 DTTGAGC-----AVATESMTFTLISVVMLLP 569
            |....|.     :.|.|.||.....||.|||
  Fly   721 DAGHDGANDNRSSDAPEKMTLRRALVVYLLP 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GPC5	NP_004457.1	Glypican	12..569	CDD:460084	154/679 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..375		3/31 (10%)
dlp	NP_524071.2	Glypican	79..619	CDD:460084	119/544 (22%)