DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GPC5 and dally

DIOPT Version :9

Sequence 1:	NP_004457.1	Gene:	GPC5 / 2262	HGNCID:	4453	Length:	572	Species:	Homo sapiens
Sequence 2:	NP_001246685.1	Gene:	dally / 39013	FlyBaseID:	FBgn0263930	Length:	626	Species:	Drosophila melanogaster

Alignment Length:	596	Identity:	159/596 - (26%)
Similarity:	254/596 - (42%)	Gaps:	100/596 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    30 CEEVRKLFQ---------WRLLGAVRGLPDSPRAGPDLQVCISKKPTCCTRKMEERYQIAARQDM 85
            |:.|:..|:         :...||:.|                  ..||....|...:..|....
  Fly    69 CDAVKSYFESIDIKSSGTYSEKGAICG------------------GNCCNNATELELRDKAAGMF 115

Human    86 QQFLQTSSSTLKFLISRNAAAFQETLETLIKQAENYTSILFCSTYRNMALEAAASVQEFFTDVGL 150
            :|.|...:|:|:.::..||..||..:..|.:.:||.|..||...|..|...:...:.:.:|::..
  Fly   116 EQLLHHHTSSLRGVLETNAKQFQSHVLELAQISENMTHSLFSKVYTRMVPSSRMMIHQLYTEIMN 180

Human   151 YLF------------------GADVNPEEFVNRFFDSLFPLVYN---HLINPGVTDSSLEYSECI 194
            :|.                  ....|.||.|..||..|||:.|:   ||....:.|...:|..|:
  Fly   181 HLIYTSNYTNSNGQLGRRGIGSVQSNLEEAVRHFFVQLFPVAYHQMVHLSKNNLGDLHEDYVNCL 245

Human   195 RMARRDVSPFGNIPQRVMGQMGRSLLPSRTFLQALNLGIEVINTTDYLH---FSKECSRALLKMQ 256
            :....::.|||:|||:|...:|:|:..|..|:.||....||::..|.|:   .:..|...||||.
  Fly   246 QHNFDEMHPFGDIPQQVQSNLGKSVHMSNVFMNALLQAAEVLSEADALYGEQLTDTCKLHLLKMH 310

Human   257 YCPHCQG-----LALTKPCMGYCLNVMRGCLAHMAE-LNPHWHAYIRSLEELSDAMHGTYDIG-- 313
            |||:|.|     .:.||.|.|||.||||||.|..|. |:..|...:.||..|. ..|...|.|
  Fly   311 YCPNCNGHHSSSRSETKLCYGYCKNVMRGCSAEYAGLLDSPWSGVVDSLNNLV-TTHILSDTGII 374

Human   314 HVLLNFHLLVNDAVLQAHLNGQKLLEQVNRICGRPVRTPTQSPRCSFDQSKEKHGMKTTTRNSEE 378
            :|:.:.....::|::.|..||.:|.::|.:.||.|..||..|..........|:.:|..|.....
  Fly   375 NVIKHLQTYFSEAIMAAMHNGPELEKKVKKTCGTPSLTPYSSGEPDARPPPHKNNVKWATDPDPG 439

Human   379 TLANRRKEFINSLRLYRSFYGGLADQLCANELAAADGLPCWNGEDIVKSYTQRVVGNGIKAQSGN 443
            .:.     |::::...:.||..:.|..|..:..:.|...||:| |....|||.::..|..:|..|
  Fly   440 MVL-----FLSTIDKSKEFYTTIVDNFCDEQQHSRDDHSCWSG-DRFGDYTQLLINPGTDSQRYN 498

Human   444 PEV--KVKGIDPVINQIIDKLKHVVQLLQGRSP----------KPDKWELLQLGSGGGMVEQVSG 496
            |||  ..|.....:|:::|||..:.:.:...:|          :.|..|    |||||  |...|
  Fly   499 PEVPFNAKAQTGKLNELVDKLFKIRKSIGAAAPSNSIQATHDIQNDMGE----GSGGG--EGQIG 557

Human   497 DCDDEDG---CGGSGSGEVKRTLKITDWMP-DDMNFSDVKQIHQTDTGSTLDTTGAGCAVATESM 557
            |.::|.|   ..|.|||:...|       | ::...:...::...|:|.|     :|......:.
  Fly   558 DDEEEYGGAHGSGDGSGDGPHT-------PIEESEGTTTNEVESRDSGKT-----SGSNPLEGTA 610

Human   558 TFTLISVVMLL 568
            |:.|:::|.:|
  Fly   611 TWMLLTLVTML 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPC5	NP_004457.1	Glypican	12..569	CDD:307347	159/596 (27%)
GPC5	NP_004457.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..375		4/19 (21%)
dally	NP_001246685.1	Glypican	51..622	CDD:279494	159/596 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147854
Domainoid	1	1.000	186	1.000	Domainoid score	I3356
eggNOG	1	0.900	-	-		E1_KOG3821
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3285
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7032
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1097767at2759
OrthoFinder	1	1.000	-	-		FOG0003365
OrthoInspector	1	1.000	-	-		oto90276
orthoMCL	1	0.900	-	-		OOG6_109158
Panther	1	1.100	-	-	O	PTHR10822
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4978
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.660