DRSC/TRiP Functional Genomics Resources

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Protein Alignment FGFR3 and LSB1

DIOPT Version :10

Sequence 1:XP_006713931.1 Gene:FGFR3 / 2261 HGNCID:3690 Length:811 Species:Homo sapiens
Sequence 2:NP_011652.1 Gene:LSB1 / 853037 SGDID:S000003368 Length:241 Species:Saccharomyces cerevisiae


Alignment Length:215 Identity:49/215 - (22%)
Similarity:69/215 - (32%) Gaps:81/215 - (37%)


- Green bases have known domain annotations that are detailed below.


Human   614 SQKCIHRDLA-ARNVL--VTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKW----MAP---- 667
            |...::|.|. .||.|  :.|.||       ::.|:..|      .|.:||.||    .:|    
Yeast     2 SASLVNRSLKNIRNELEFLKESNV-------ISGDIFEL------INSKLPEKWDGNQRSPQNAD 53

Human   668 -----EALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK-------P 720
                 |||:|  :..|.|    |.|         |...|..::.|.|:..:.:|...       |
Yeast    54 TEEYVEALYD--FEAQQD----GDL---------SLKTGDKIQVLEKISPDWYRGKSNNKIGIFP 103

Human   721 ANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDQEYLDLSAPFEQYSPGGQDTPSS 785
            ||     |:            :|.|.:...........:||...   .|.|...|.|.....||.
Yeast   104 AN-----YV------------KPAFTRSASPKSAEAASSSTVSR---PSVPPPSYEPAASQYPSQ 148

Human   786 SSSGDDSVFAHDLLPPAPPS 805
            ..|.          |.|||:
Yeast   149 QVSA----------PYAPPA 158

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FGFR3XP_006713931.1 Ig 37..109 CDD:472250
Ig strand B 57..61 CDD:409362
Ig strand C 69..75 CDD:409362
Ig strand E 92..96 CDD:409362
IgI_2_FGFR 151..245 CDD:409443
Ig strand A 151..154 CDD:409443
Ig strand A' 162..167 CDD:409443
Ig strand B 171..179 CDD:409443
Ig strand C 185..190 CDD:409443
Ig strand C' 193..195 CDD:409443
Ig strand D 204..207 CDD:409443
Ig strand E 211..216 CDD:409443
Ig strand F 225..232 CDD:409443
Ig strand G 235..245 CDD:409443
IgI_3_FGFR 253..354 CDD:409363
Ig strand A 253..256 CDD:409363
Ig strand A' 260..264 CDD:409363
Ig strand B 272..279 CDD:409363
Ig strand C 283..290 CDD:409363
Ig strand D 305..310 CDD:409363
Ig strand E 321..326 CDD:409363
Ig strand F 334..342 CDD:409363
Ig strand G 345..353 CDD:409363
Protein Kinases, catalytic domain 463..797 CDD:473864 45/205 (22%)
LSB1NP_011652.1 SH3 55..108 CDD:214620 17/84 (20%)
PRK12323 <100..>156 CDD:481241 16/85 (19%)
Blue background indicates that the domain is not in the aligned region.

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