DRSC/TRiP Functional Genomics Resources

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Protein Alignment FGFR3 and Cad96Ca

DIOPT Version :10

Sequence 1:XP_006713931.1 Gene:FGFR3 / 2261 HGNCID:3690 Length:811 Species:Homo sapiens
Sequence 2:NP_651349.1 Gene:Cad96Ca / 43026 FlyBaseID:FBgn0022800 Length:773 Species:Drosophila melanogaster


Alignment Length:801 Identity:228/801 - (28%)
Similarity:343/801 - (42%) Gaps:172/801 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    27 TEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGG-----GPMGPTVWVKDGTGLVPSER 86
            :|...||:..:....|....:.|:||    :|.....|||     .|......:...||:|....
  Fly    67 SETEKVGQIIDRVRAEDPDGDDLIFG----IEPRFSLPGGENDASPPEKIPFQIDRETGVVTLNE 127

Human    87 VLVGPQ------RLQVLNASH--------------EDSGAYSCRQRLTQRV--LCHFSVRVTDAP 129
            .|.|..      .:.|.:.|:              |:|..|..:..::..|  :..|..|....|
  Fly   128 SLAGRAGQNFLIYITVTDGSYTAKNEVFINILGERENSSGYRPQTSISNVVHNISQFLPRFDQLP 192

Human   130 SSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGN----PTPSISWLK 190
            ......:|...:...|       |..|         ||..|.  |..|..||    |.|:|..::
  Fly   193 GVQSIRNGLPNSRPGG-------WYPP---------VPQNNI--FGPPPFGNNYPPPPPNIPGVR 239

Human   191 ---NGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHR 252
               :|.|.:.:..:      .....:.:.|..|..|...|.:..|  .|.|              
  Fly   240 GEQSGEEEQPDEEV------TPTTPVRISSTTPKSRTKLTPITAN--NSTR-------------- 282

Human   253 PILQAGLPANQTAVLGSD--------VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVL 309
              :::.:||..|...|..        ..|..|  |...|.:     |.|.|..|.      :.||
  Fly   283 --VESAIPAETTTPSGGHHNNSSSPITIFSLK--SGTIPIV-----VTVGGFFVA------IAVL 332

Human   310 KSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAF-----------WLSVHGPRAAEE 363
            .:::.......:...|....|:   |.|.:.:|...::....           |   .||.|...
  Fly   333 LAYLCRRRLCAISRTLKKTKEK---EELAKKSNQSQLSSTLTDDSRNSMVMQQW---QGPVAFAN 391

Human   364 ELV--EADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSP--PKKGLGSPTVHKISRFPLKRQ 424
            ..|  |.|:...:....||.|            ||...:.||  |..|.|.|             
  Fly   392 RYVPWERDQQMGIATSQLSTG------------VTNGGVSSPGVPSPGTGEP------------- 431

Human   425 VTVSLESNASMSSNTPLVRIARLSSGEGPTLA--NVSELELPADPKWELSRARLTLGKPLGEGCF 487
                 .||.....         |:.|.|.:.|  |....|...| :||..|.||.....||||.|
  Fly   432 -----GSNLGPGC---------LTGGAGSSGAPENAFAGEANCD-RWEFPRYRLKFFNILGEGAF 481

Human   488 GQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQG 552
            |||...||..|:.:...  .|||||.||:.||:.|..||:||:|:||.:..|.|:::|||.||..
  Fly   482 GQVWRCEATNINGNEGI--TTVAVKTLKESATEVDRKDLLSELEVMKSLEPHINVVHLLGCCTDK 544

Human   553 GPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKC 617
            .|.:|::||..:|.|:.:||:.|   .:..:.........||..||.|..||||:||:||.|:..
  Fly   545 DPTFVILEYVNRGKLQTYLRSSR---AERHYGNTHGKSNVLTSCDLTSFMYQVAKGMDYLTSRGI 606

Human   618 IHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 682
            |||||||||:|:|:|:..|:||||.||||.....|::.:.|:||::|||.|:|:|.:::.:||:|
  Fly   607 IHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIW 671

Human   683 SFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQ 747
            |||:|:|||.|||.:|||||...::.:.:::|:|::||.:|..:||.||..||...|.:||.|.:
  Fly   672 SFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAE 736

Human   748 LVEDLDRVLTVTSTDQEYLDL 768
            :::.||::|   .|:.:|::|
  Fly   737 IIQMLDKLL---HTEMDYIEL 754

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FGFR3XP_006713931.1 Ig 37..109 CDD:472250 19/96 (20%)
Ig strand B 57..61 CDD:409362 1/3 (33%)
Ig strand C 69..75 CDD:409362 0/5 (0%)
Ig strand E 92..96 CDD:409362 0/9 (0%)
IgI_2_FGFR 151..245 CDD:409443 21/100 (21%)
Ig strand A 151..154 CDD:409443 0/2 (0%)
Ig strand A' 162..167 CDD:409443 0/4 (0%)
Ig strand B 171..179 CDD:409443 2/7 (29%)
Ig strand C 185..190 CDD:409443 1/4 (25%)
Ig strand C' 193..195 CDD:409443 0/1 (0%)
Ig strand D 204..207 CDD:409443 0/2 (0%)
Ig strand E 211..216 CDD:409443 0/4 (0%)
Ig strand F 225..232 CDD:409443 1/6 (17%)
Ig strand G 235..245 CDD:409443 2/9 (22%)
IgI_3_FGFR 253..354 CDD:409363 20/119 (17%)
Ig strand A 253..256 CDD:409363 0/2 (0%)
Ig strand A' 260..264 CDD:409363 2/3 (67%)
Ig strand B 272..279 CDD:409363 2/6 (33%)
Ig strand C 283..290 CDD:409363 1/6 (17%)
Ig strand D 305..310 CDD:409363 1/4 (25%)
Ig strand E 321..326 CDD:409363 0/4 (0%)
Ig strand F 334..342 CDD:409363 2/7 (29%)
Ig strand G 345..353 CDD:409363 0/18 (0%)
Protein Kinases, catalytic domain 463..797 CDD:473864 134/306 (44%)
Cad96CaNP_651349.1 Cadherin_repeat 65..164 CDD:206637 19/100 (19%)
PTKc 474..742 CDD:270623 122/272 (45%)

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