Protein Alignment FGFR3 and tor

DIOPT Version :9

• Sequence 1: XP_006713931.1
• Gene: FGFR3 / 2261
• HGNCID: 3690
• Length: 811
• Species: Homo sapiens
• Sequence 2: NP_476762.1
• Gene: tor / 35717
• FlyBaseID: FBgn0003733
• Length: 923
• Species: Drosophila melanogaster
• Alignment Length: 556
• Identity: 167/556 - (30%)
• Similarity: 242/556 - (43%)
• Gaps: 184/556 - (33%)

Human   362 EEELVEADEAGSVYAG----------ILSYG--VGFFLFILV-------VAAVTLCRLRSPPKKG 407
            |..||.....|...:|          :||.|  |...|||:|       :.::|.||......:.
  Fly   365 EVHLVAQSAGGKNVSGLTLDKVHRGVLLSEGNMVKLVLFIIVPICCILMLCSLTFCRRNRSEVQA 429

Human   408 LGSPTVH-KISRFPLKRQVTVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWEL 471
            |...... |.|.|.|      ||..::.:        :..||:.|  :|..:.|||:  :|.
  Fly   430 LQMDAKDAKASEFHL------SLMDSSGL--------LVTLSANE--SLEVMDELEV--EPH--- 473

Human   472 SRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMI 536
               .:.|...||||.||.|    ..|:.|.|     .||||:|||:..|:|:.....|::|:|.:
  Fly   474 ---SVLLQDVLGEGAFGLV----RRGVYKKR-----QVAVKLLKDEPNDEDVYAFKCEIQMLKAV 526

Human   537 GKHKNIINLLGACTQ-GGPLYVLVEYAAKGNLREFLRA--------------------------R 574
            |||.||:.::|..|: ...:.:|:||.:.|:|:.|||.                          .
  Fly   527 GKHPNIVGIVGYSTRFSNQMMLLIEYCSLGSLQNFLREEWKFRQEQNAIGLKKNLEQNVDNRRFN 591

Human   575 RPP--------------------------------------------------GLD--------Y 581
            |.|                                                  ||:        |
  Fly   592 RLPRNSIHDRIEDINNSMLSTVEEESESDQTHSSRCETYTLTRITNAADNKGYGLEDIENIGGSY 656

Human   582 SFDTCKPPEEQ---------------------------------------------LTFKDLVSC 601
            ...|.:.|:::                                             |.:.||:..
  Fly   657 IPKTAEAPKDRPKRKLKPQPKKDSKQDFKSDNKKRIFENKEYFDCLDSSDTKPRIPLKYADLLDI 721

Human   602 AYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKT-TNGRLPVKWM 665
            |.|||.|||:||..|.:||||||||||::.|..:|||||||:|||::.:.|:|: .:|:||:||:
  Fly   722 AQQVAVGMEFLAQNKVVHRDLAARNVLISVDRSIKIADFGLSRDVYHENVYRKSGGSGKLPIKWL 786

Human   666 APEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMI 730
            |.|:|..:|||.|||||||||||:||.||||.|||.:...:|.:||::||||.:|..||.:::.:
  Fly   787 ALESLTHQVYTSQSDVWSFGVLLYEITTLGGMPYPSVSPSDLLQLLRQGHRMKRPEGCTQEMFSL 851

Human   731 MRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDQEYL 766
            |..||.:.||.||||..|...|..::..|:...|.|
  Fly   852 MESCWSSVPSHRPTFSALKHRLGGMILATNDVPERL 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGFR3	XP_006713931.1	IGc2	53..110	CDD:197706
		IG	54..125	CDD:214652
		Ig2_FGFR	161..245	CDD:143265
		IG_like	171..245	CDD:214653
		IG_like	260..355	CDD:214653
		Ig3_FGFR	268..356	CDD:143175
		PKc_like	463..797	CDD:304357	137/435 (31%)
		Pkinase_Tyr	476..752	CDD:285015	132/406 (33%)
tor	NP_476762.1	FN3	199..261	CDD:214495
		STYKc	475..873	CDD:214568	132/406 (33%)
		PTKc	479..873	CDD:270623	131/402 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910