Protein Alignment FGFR3 and Fgfr3

DIOPT Version :10

• Sequence 1: XP_006713931.1
• Gene: FGFR3 / 2261
• HGNCID: 3690
• Length: 811
• Species: Homo sapiens
• Sequence 2: NP_001156689.1
• Gene: Fgfr3 / 14184
• MGIID: 95524
• Length: 802
• Species: Mus musculus
• Alignment Length: 811
• Identity: 745/811 - (91%)
• Similarity: 765/811 - (94%)
• Gaps: 9/811 - (1%)

Human     1 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPG 65
            |..|||.|..||||  ||||:||..|.|||||.||||||||||.||||:.|||||.|||||.|||
Mouse     1 MVVPACVLVFCVAV--VAGATSEPPGPEQRVVRRAAEVPGPEPSQQEQVAFGSGDTVELSCHPPG 63

Human    66 GGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPS 130
            |.|.|||||.|||||||.|.|:||||||||||||||||:|.|||:.|||:|||||||||||||||
Mouse    64 GAPTGPTVWAKDGTGLVASHRILVGPQRLQVLNASHEDAGVYSCQHRLTRRVLCHFSVRVTDAPS 128

Human   131 SGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREF 195
            |||||||||.||    ||||||||||||||||||||||||||||||||||||||||||||||:||
Mouse   129 SGDDEDGEDVAE----DTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGKEF 189

Human   196 RGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLP 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   190 RGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLP 254

Human   261 ANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRL 325
            |||||:|||||||||||||||||||||||||||||||||||||||||||||||||:||||.||||
Mouse   255 ANQTAILGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISENVEADARLRL 319

Human   326 ANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLFIL 390
            ||||||||||||||||||||||||||||.||||:||||||:|.|||||||||:|||||.||||||
Mouse   320 ANVSERDGGEYLCRATNFIGVAEKAFWLRVHGPQAAEEELMETDEAGSVYAGVLSYGVVFFLFIL 384

Human   391 VVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVTVSLESNASMSSNTPLVRIARLSSGEGPTL 455
            |||||.|||||||||||||||||||:||||||||  ||||||:||:|||||||||||||||||.|
Mouse   385 VVAAVILCRLRSPPKKGLGSPTVHKVSRFPLKRQ--VSLESNSSMNSNTPLVRIARLSSGEGPVL 447

Human   456 ANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATD 520
            ||||||||||||||||||.||||||||||||||||||||||||||||.|||||||||||||||||
Mouse   448 ANVSELELPADPKWELSRTRLTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATD 512

Human   521 KDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDT 585
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||.
Mouse   513 KDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGMDYSFDA 577

Human   586 CKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLD 650
            |:.||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   578 CRLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLD 642

Human   651 YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH 715
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   643 YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH 707

Human   716 RMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDQEYLDLSAPFEQYSPGGQ 780
            ||||||:|||||||||||||||.||||||||||||||||:||||||| ||||||.||||||||||
Mouse   708 RMDKPASCTHDLYMIMRECWHAVPSQRPTFKQLVEDLDRILTVTSTD-EYLDLSVPFEQYSPGGQ 771

Human   781 DTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT 811
            ||||||||||||||.||||||.|||:||.||
Mouse   772 DTPSSSSSGDDSVFTHDLLPPGPPSNGGPRT 802

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGFR3	XP_006713931.1	Ig	37..109	CDD:472250	58/71 (82%)
		Ig strand B	57..61	CDD:409362	3/3 (100%)
		Ig strand C	69..75	CDD:409362	4/5 (80%)
		Ig strand E	92..96	CDD:409362	3/3 (100%)
		IgI_2_FGFR	151..245	CDD:409443	92/93 (99%)
		Ig strand A	151..154	CDD:409443	2/2 (100%)
		Ig strand A'	162..167	CDD:409443	4/4 (100%)
		Ig strand B	171..179	CDD:409443	7/7 (100%)
		Ig strand C	185..190	CDD:409443	4/4 (100%)
		Ig strand C'	193..195	CDD:409443	0/1 (0%)
		Ig strand D	204..207	CDD:409443	2/2 (100%)
		Ig strand E	211..216	CDD:409443	4/4 (100%)
		Ig strand F	225..232	CDD:409443	6/6 (100%)
		Ig strand G	235..245	CDD:409443	9/9 (100%)
		IgI_3_FGFR	253..354	CDD:409363	97/100 (97%)
		Ig strand A	253..256	CDD:409363	2/2 (100%)
		Ig strand A'	260..264	CDD:409363	3/3 (100%)
		Ig strand B	272..279	CDD:409363	6/6 (100%)
		Ig strand C	283..290	CDD:409363	6/6 (100%)
		Ig strand D	305..310	CDD:409363	4/4 (100%)
		Ig strand E	321..326	CDD:409363	3/4 (75%)
		Ig strand F	334..342	CDD:409363	7/7 (100%)
		Ig strand G	345..353	CDD:409363	7/7 (100%)
		Protein Kinases, catalytic domain	463..797	CDD:473864	320/333 (96%)
Fgfr3	NP_001156689.1	ig	46..110	CDD:395002	50/63 (79%)
		Ig strand B	55..59	CDD:409353	3/3 (100%)
		Ig strand C	69..73	CDD:409353	3/3 (100%)
		Ig strand E	91..94	CDD:409353	2/2 (100%)
		Ig strand F	104..108	CDD:409353	2/3 (67%)
		IgI_2_FGFR	145..239	CDD:409443	92/93 (99%)
		Ig strand A	145..148	CDD:409443	2/2 (100%)
		Ig strand A'	156..161	CDD:409443	4/4 (100%)
		Ig strand B	165..173	CDD:409443	7/7 (100%)
		Ig strand C	179..184	CDD:409443	4/4 (100%)
		Ig strand C'	187..189	CDD:409443	0/1 (0%)
		Ig strand D	198..201	CDD:409443	2/2 (100%)
		Ig strand E	205..210	CDD:409443	4/4 (100%)
		Ig strand F	219..226	CDD:409443	6/6 (100%)
		Ig strand G	229..239	CDD:409443	9/9 (100%)
		IgI_3_FGFR	247..347	CDD:409363	96/99 (97%)
		Ig strand A	247..250	CDD:409363	2/2 (100%)
		Ig strand A'	254..258	CDD:409363	3/3 (100%)
		Ig strand B	266..273	CDD:409363	6/6 (100%)
		Ig strand C	277..284	CDD:409363	6/6 (100%)
		Ig strand D	299..304	CDD:409363	4/4 (100%)
		Ig strand E	315..320	CDD:409363	3/4 (75%)
		Ig strand F	328..336	CDD:409363	7/7 (100%)
		Ig strand G	339..347	CDD:409363	7/7 (100%)
		PTKc_FGFR3	455..788	CDD:173652	320/333 (96%)