DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FGFR3 and fgfr3

DIOPT Version :9

Sequence 1:	XP_006713931.1	Gene:	FGFR3 / 2261	HGNCID:	3690	Length:	811	Species:	Homo sapiens
Sequence 2:	XP_012812743.1	Gene:	fgfr3 / 100196923	XenbaseID:	XB-GENE-479255	Length:	829	Species:	Xenopus tropicalis

Alignment Length:	802	Identity:	583/802 - (72%)
Similarity:	654/802 - (81%)	Gaps:	15/802 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     6 CALAL-CVAVAIVAGAS-SESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGP 68
            |.|.| .|||..|..|. ..:|..|.|...:|::....|....::|:|..|:.:||||.......
Frog    25 CTLCLFLVAVNCVPAARLPVTLPGEDRASRKASDYITVEQPPFDELMFTIGETIELSCAAEDAST 89

Human    69 MGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGD 133
              .|.|.|||..:||:.|.......|:::|.|::|||.||||...:..:|.:|::||||.|||||
Frog    90 --TTKWFKDGIAIVPNNRTNTRQGLLKIINISYDDSGIYSCRLWHSTEILRNFTIRVTDLPSSGD 152

Human   134 DEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGE 198
            |||.:||..:   |...|.||:||:|||||.|||||||:||||||||||||:|.|||||:|||||
Frog   153 DEDDDDEETE---DREPPRWTQPEKMDKKLTAVPAANTIRFRCPAAGNPTPTIHWLKNGKEFRGE 214

Human   199 HRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQ 263
            ||||||||||||||||||||||||:||||||||||:|||||||.|||||||.|||||||||||||
Frog   215 HRIGGIKLRHQQWSLVMESVVPSDKGNYTCVVENKYGSIRQTYQLDVLERSSHRPILQAGLPANQ 279

Human   264 TAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANV 328
            |.|:||||||||||||||||||||||||||||||.||||.||||||:|: :...|.|..|.|.||
Frog   280 TVVIGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKYGPDGDPYVTVLQSF-TNGTEVDTTLSLKNV 343

Human   329 SERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAE--EELVEADEAGSVYAGILSYGVGFFLFILV 391
            :|...|:|:|||.|||||||.:|||.::.|.:||  |:......:.:....::|...||.|  ||
Frog   344 TETHEGQYVCRANNFIGVAEASFWLHIYKPASAEPVEKPTTTSSSSTTVLIVVSVITGFIL--LV 406

Human   392 VAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVTVSLESNASMSSNTPLVRIARLSSGEGPTLA 456
            :..||. |::.|.||.:.:|.|||:|:|||||| .||||||:||:||||||||..|||.:|..||
Frog   407 IIFVTY-RVKVPSKKAMSAPPVHKVSKFPLKRQ-QVSLESNSSMNSNTPLVRITHLSSSDGTMLA 469

Human   457 NVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDK 521
            |||||.||.||||||.|.||||||||||||||||||||||||:|:|..|||||||||||||||||
Frog   470 NVSELGLPLDPKWELLRTRLTLGKPLGEGCFGQVVMAEAIGIEKERPNKPVTVAVKMLKDDATDK 534

Human   522 DLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTC 586
            ||||||||||||||||||||||||||||||.||||||||||:||||||:|:||||||:|||||||
Frog   535 DLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLKARRPPGMDYSFDTC 599

Human   587 KPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDY 651
            |.|.||||||||||||||||||||||||||||||||||||||||:||||||||||||||:||:||
Frog   600 KIPAEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTDDNVMKIADFGLARDIHNIDY 664

Human   652 YKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHR 716
            ||||||||||||||||||||||:|||||||||:||||||.|||||||||||||||||||||||||
Frog   665 YKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSYGVLLWETFTLGGSPYPGIPVEELFKLLKEGHR 729

Human   717 MDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDQEYLDLSAPFEQYSPGGQD 781
            |||||||||:|||||||||||.|||||||||||||||||||||||| ||||||.|||||||..||
Frog   730 MDKPANCTHELYMIMRECWHAVPSQRPTFKQLVEDLDRVLTVTSTD-EYLDLSVPFEQYSPACQD 793

Human   782 TPSSSSSGDDSVFAHDLLPPAP 803
            :.|:.|||||||||||:||..|
Frog   794 SHSTCSSGDDSVFAHDILPDEP 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FGFR3	XP_006713931.1	IGc2	53..110	CDD:197706	21/56 (38%)
		IG	54..125	CDD:214652	25/70 (36%)
		Ig2_FGFR	161..245	CDD:143265	75/83 (90%)
		IG_like	171..245	CDD:214653	66/73 (90%)
		IG_like	260..355	CDD:214653	69/94 (73%)
		Ig3_FGFR	268..356	CDD:143175	63/87 (72%)
		PKc_like	463..797	CDD:304357	303/333 (91%)
		Pkinase_Tyr	476..752	CDD:285015	256/275 (93%)
fgfr3	XP_012812743.1	IGc2	74..129	CDD:197706	21/56 (38%)
		Ig2_FGFR	177..261	CDD:143265	75/83 (90%)
		Ig3_FGFR	284..371	CDD:319280	63/87 (72%)
		PTKc_FGFR3	476..809	CDD:173652	303/333 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	543	1.000	Domainoid score	I3062
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55437
Inparanoid	1	1.050	1129	1.000	Inparanoid score	I2499
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG50158
OrthoDB	1	1.010	-	-		D119660at33208
OrthoFinder	1	1.000	-	-		FOG0000923
OrthoInspector	1	1.000	-	-		oto158890
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6544
SonicParanoid	1	1.000	-	-		X537
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110