DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FGFR1 and fgfr1a

DIOPT Version :9

Sequence 1:	XP_011542745.1	Gene:	FGFR1 / 2260	HGNCID:	3688	Length:	865	Species:	Homo sapiens
Sequence 2:	XP_009302578.1	Gene:	fgfr1a / 30705	ZFINID:	ZDB-GENE-980526-255	Length:	811	Species:	Danio rerio

Alignment Length:	769	Identity:	538/769 - (69%)
Similarity:	638/769 - (82%)	Gaps:	19/769 - (2%)

- Green bases have known domain annotations that are detailed below.

Human    40 LLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGV 104
            ||..:||:|..| .::..|.:.::     ||.|..|:.:..|:.|:|.|:.::|.|.:.|.:|.|
Zfish    11 LLLISVLLTQAL-QSQGRPAIQDE-----APAEPTSYTLDSGEKLELSCKAKEDTQKVTWTKDLV 69

Human   105 QLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSS 169
            .|.:...||:..:::|::...|.|||||||.....:.:.|.||:::|:       |::|:.||||
Zfish    70 PLVDGEHTRLRNDQMEIEKVEPTDSGLYACFAQGLNSNHTEYFNISVT-------DEEDEVDSSS 127

Human   170 EEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDH 234
            ||.:..|.:  .:|:||.|..|:|||||||||||:|||||:|.::|.|.|||:|||||||||.|.
Zfish   128 EEAKLSNDQ--NLPMAPVWAQPDKMEKKLHAVPASKTVKFRCQANGNPTPTLKWLKNGKEFKRDQ 190

Human   235 RIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKT 299
            ||||:|||...|:|||:||||||:|||||:|||.:||||||||||||||||||||||||||||:|
Zfish   191 RIGGFKVREHMWTIIMESVVPSDRGNYTCLVENRHGSINHTYQLDVVERSPHRPILQAGLPANRT 255

Human   300 VALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 364
            ..:||:|||.|||:||||||||||||||||||:.|||.||||:.||.:|||::|  .:||.|.||
Zfish   256 AVVGSDVEFECKVFSDPQPHIQWLKHIEVNGSRYGPDGLPYVRALKNSGVNSSD--TQVLTLYNV 318

Human   365 SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEE-RPAVMTSPLYLEIIIYCTGAFLISCMVGSVI 428
            :.|.:|||.|...|.||.::.||||||::.|:. .|..:.:..|||::|||.|.|||..|||:.:
Zfish   319 TEEQSGEYICKVSNYIGQANQSAWLTVVKHLQAVPPTQLPNQTYLEVLIYCVGFFLICVMVGTAV 383

Human   429 VYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGV 493
            :.||.|..|||||:||:||||||||||||||||||.|||:||:||.:|||||||||||:|||:||
Zfish   384 LAKMHSSAKKSDFNSQLAVHKLAKSIPLRRQVTVSVDSSSSMHSGGMLVRPSRLSSSGSPMLSGV 448

Human   494 SEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDL 558
            ||||||:|||||:.||||||||||||||||||::|||:|:||:||||:|||||||||||||||||
Zfish   449 SEYELPQDPRWEVQRDRLVLGKPLGEGCFGQVMMAEAMGMDKEKPNRITKVAVKMLKSDATEKDL 513

Human   559 SDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHN 623
            |||||||||||:|||||||||||||||||||||||||:|:||||||||:.|||||:||||||...
Zfish   514 SDLISEMEMMKIIGKHKNIINLLGACTQDGPLYVIVEFAAKGNLREYLRVRRPPGMEYCYNPDQV 578

Human   624 PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYK 688
            |.|.:|.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   579 PVENMSIKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYK 643

Human   689 KTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMD 753
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   644 KTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMD 708

Human   754 KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQVLHPDLTTHL 807
            :||.||:|||||||||||||||||||||||||||||.:::||||. :.||:..|
Zfish   709 RPSTCTHELYMMMRDCWHAVPSQRPTFKQLVEDLDRTLSMTSNQE-YLDLSVSL 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FGFR1	XP_011542745.1	Ig1_FGFR	73..151	CDD:143174	25/77 (32%)
		IG_like	77..151	CDD:214653	24/73 (33%)
		I-set	193..280	CDD:254352	66/86 (77%)
		Ig2_FGFR	196..280	CDD:143265	63/83 (76%)
		IG_like	295..391	CDD:214653	60/95 (63%)
		Ig3_FGFR	303..392	CDD:143175	57/88 (65%)
		PTKc_FGFR1	497..797	CDD:270678	270/299 (90%)
		Pkinase_Tyr	511..787	CDD:285015	253/275 (92%)
fgfr1a	XP_009302578.1	Ig	28..116	CDD:416386	29/92 (32%)
		Ig strand A	28..31	CDD:409353	1/2 (50%)
		Ig strand A'	38..44	CDD:409353	1/5 (20%)
		Ig strand B	47..57	CDD:409353	3/9 (33%)
		Ig strand C	61..66	CDD:409353	1/4 (25%)
		Ig strand C'	69..71	CDD:409353	1/1 (100%)
		Ig strand D	76..80	CDD:409353	2/3 (67%)
		Ig strand E	83..88	CDD:409353	1/4 (25%)
		Ig strand F	94..103	CDD:409353	6/8 (75%)
		Ig strand G	106..116	CDD:409353	3/9 (33%)
		Ig	142..236	CDD:416386	69/93 (74%)
		Ig strand A	142..145	CDD:409353	1/2 (50%)
		Ig strand A'	153..158	CDD:409353	4/4 (100%)
		Ig strand B	162..170	CDD:409353	5/7 (71%)
		Ig strand C	176..181	CDD:409353	3/4 (75%)
		Ig strand C'	184..186	CDD:409353	1/1 (100%)
		Ig strand D	195..198	CDD:409353	1/2 (50%)
		Ig strand E	202..207	CDD:409353	3/4 (75%)
		Ig strand F	216..223	CDD:409353	5/6 (83%)
		Ig strand G	226..236	CDD:409353	9/9 (100%)
		Ig	244..345	CDD:416386	67/102 (66%)
		Ig strand A	244..247	CDD:409353	2/2 (100%)
		Ig strand A'	251..255	CDD:409353	3/3 (100%)
		Ig strand B	263..270	CDD:409353	5/6 (83%)
		Ig strand C	274..281	CDD:409353	6/6 (100%)
		Ig strand D	296..301	CDD:409353	2/4 (50%)
		Ig strand E	311..316	CDD:409353	2/4 (50%)
		Ig strand F	324..332	CDD:409353	4/7 (57%)
		Ig strand G	335..343	CDD:409353	3/7 (43%)
		FGFR3_TM	358..387	CDD:407957	13/28 (46%)
		PTKc_FGFR1	452..753	CDD:270678	271/300 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194331452
Domainoid	1	1.000	536	1.000	Domainoid score	I2296
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69065
Inparanoid	1	1.050	1221	1.000	Inparanoid score	I1546
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50158
OrthoDB	1	1.010	-	-		D119660at33208
OrthoFinder	1	1.000	-	-		FOG0000923
OrthoInspector	1	1.000	-	-		oto48538
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6544
SonicParanoid	1	1.000	-	-		X537
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	15	15.440