DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ALDOA and Ald1

DIOPT Version :9

Sequence 1:	NP_001230106.1	Gene:	ALDOA / 226	HGNCID:	414	Length:	418	Species:	Homo sapiens
Sequence 2:	NP_001262985.1	Gene:	Ald1 / 43183	FlyBaseID:	FBgn0000064	Length:	363	Species:	Drosophila melanogaster

Alignment Length:	365	Identity:	252/365 - (69%)
Similarity:	292/365 - (80%)	Gaps:	3/365 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    54 TMPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLL 118
            |..:.||  :.|.:.||.:||.:||||||||||||||..::.||||.||.||||:|||.|||||.
  Fly     2 TTYFNYP--SKELQDELREIAQKIVAPGKGILAADESGPTMGKRLQDIGVENTEDNRRAYRQLLF 64

Human   119 TADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLD 183
            :.|.::...|.||||||||||||||||.||.:::|.||.::|||||||||||.|:..|.||||||
  Fly    65 STDPKLAENISGVILFHETLYQKADDGTPFAEILKKKGIILGIKVDKGVVPLFGSEDEVTTQGLD 129

Human   184 GLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPD 248
            .|:.|||||||||.||||||||||||::|||..:|:||||||||||||||...||||||||:|||
  Fly   130 DLAARCAQYKKDGCDFAKWRCVLKIGKNTPSYQSILENANVLARYASICQSQRIVPIVEPEVLPD 194

Human   249 GDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKFSHEEIAMATVTALRR 313
            |||||.|.|.|||.|||||||||||||:|||||||||||||.|.: .:|.:.||||:|||.||||
  Fly   195 GDHDLDRAQKVTETVLAAVYKALSDHHVYLEGTLLKPNMVTAGQS-AKKNTPEEIALATVQALRR 258

Human   314 TVPPAVTGITFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAA 378
            |||.||||:||||||||||||::||:|||..||::|||||||||||||||.|:||.|||||:.|.
  Fly   259 TVPAAVTGVTFLSGGQSEEEATVNLSAINNVPLIRPWALTFSYGRALQASVLRAWAGKKENIAAG 323

Human   379 QEEYVKRALANSLACQGKYTPSGQAGAAASESLFVSNHAY 418
            |.|.:|||.|||.||||.|.|......|.:.:|||:.|.|
  Fly   324 QNELLKRAKANSQACQGIYVPGSIPSFAGNANLFVAQHKY 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ALDOA	NP_001230106.1	Glycolytic	69..418	CDD:306729	247/348 (71%)
Ald1	NP_001262985.1	Glycolytic	15..363	CDD:278692	247/348 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160142
Domainoid	1	1.000	495	1.000	Domainoid score	I360
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	498	1.000	Inparanoid score	I1383
Isobase	1	0.950	-	0	Normalized mean entropy	S2120
OMA	1	1.010	-	-		QHG63159
OrthoDB	1	1.010	-	-		D342837at33208
OrthoFinder	1	1.000	-	-		FOG0000633
OrthoInspector	1	1.000	-	-		mtm8632
orthoMCL	1	0.900	-	-		OOG6_100527
Panther	1	1.100	-	-	O	PTHR11627
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2393
SonicParanoid	1	1.000	-	-		X377
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.890