Protein Alignment ABCD2 and Abcd1

DIOPT Version :10

• Sequence 1: NP_005155.1
• Gene: ABCD2 / 225
• HGNCID: 66
• Length: 740
• Species: Homo sapiens
• Sequence 2: NP_651906.1
• Gene: Abcd1 / 43772
• FlyBaseID: FBgn0039890
• Length: 730
• Species: Drosophila melanogaster
• Alignment Length: 745
• Identity: 376/745 - (50%)
• Similarity: 492/745 - (66%)
• Gaps: 68/745 - (9%)

Human     4 MLNAAADRV--KWTRSSAAKRA---ACLVAAAYAL--KTLYPIIGKRLK-----QSGHGKKKAAA 56
            :|:...||:  |...:...|.|   |.:.:|..||  |...|.: |.:.     ::..||.....
  Fly     3 VLSKYVDRIAEKCEHNGFTKHAFSYALVTSAILALTIKVTIPYV-KNVNTTSSVRTQKGKTNGQL 66

Human    57 YPA-----------AENTEIL-------HCTETICEKPSPGVNADFFKQLLELRKILFPKLVTTE 103
            .|:           ||..::|       ..|..:.|   ||:|.:|.|.|..|.||:.|:....|
  Fly    67 SPSTRDSSEEDFKLAEAEKLLVAQQLKKKATNNLVE---PGLNKEFLKHLQMLAKIMIPQAFCYE 128

Human   104 TGWLCLHSVALISRTFLSIYVAGLDGKIVKSIVEKKPRTFIIKLIKWLMIAIPATFVNSAIRYLE 168
            ||.|.:|:..||||||||||||.|:|.:||.||.|..:.|.:.|:||..||||||||||.||:||
  Fly   129 TGLLSVHTFCLISRTFLSIYVAALEGALVKFIVRKDIKQFALVLLKWFGIAIPATFVNSMIRFLE 193

Human   169 CKLALAFRTRLVDHAYETYFTNQTYYKVINMDGRLANPDQSLTEDIMMFSQSVAHLYSNLTKPIL 233
            .||:||||||||.|:|..||.||.||:|.|:|||:.|.|..|||||.:|:.|||||||:||||..
  Fly   194 SKLSLAFRTRLVRHSYRLYFKNQNYYRVSNLDGRIENADHRLTEDISVFANSVAHLYSSLTKPCF 258

Human   234 DVMLTSYTLIQTATSRGASPI-GPTLLAGLVVYATAKVLKACSPKFGKLVAEEAHRKGYLRYVHS 297
            |:||....|::::....|:.| ||.|..| |:..||.:|:..|||||:||:|||:|.||||::||
  Fly   259 DLMLIGLALMRSSKKMKANIITGPALSIG-VIALTAHILRIVSPKFGQLVSEEANRYGYLRHIHS 322

Human   298 RIIANVEEIAFYRGHKVEMKQLQKSYKALADQMNLILSKRLWYIMIEQFLMKYVWSSSGLIMVAI 362
            |||.|.||||||.||||||:||:::|..|.:||..|.:::||:||:|||.||||||.:|:|||::
  Fly   323 RIITNAEEIAFYGGHKVEMQQLRQAYNRLVNQMTTIFNQKLWFIMLEQFFMKYVWSGTGMIMVSL 387

Human   363 PIITATGFADG---EDGQKQVMVSERTEAFTTARNLLASGADAIERIMSSYKEVTELAGYTARVY 424
            ||:|.:....|   .....:..|||||:..|||||||.|.||||||:||||||:..|||||.||.
  Fly   388 PILTGSDVGLGTVPNTAISESRVSERTQYLTTARNLLISAADAIERLMSSYKEIVSLAGYTFRVA 452

Human   425 NMFWVFDEVKRGIYKRTAVIQESESHS----KNGAKVELPLSDTLAIKGKVIDVDH----GIICE 481
            .|..||:|...|:|.:|:|::.::|:.    :||..:         .||::|..|.    .|...
  Fly   453 GMMDVFEETALGVYCKTSVMESNQSNGIIEFRNGKPI---------AKGRIIYSDDPKNMSISLR 508

Human   482 NVPIITPAGEVVASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPPQH---- 542
            .||::||..::|..:|...:|.|:||||||||||||||||||||||||:|.|.|:.|.|..
  Fly   509 AVPVVTPNCDIVVPKLTLCIEPGVHLLITGPNGCGKSSLFRILSGLWPIYAGELHIPRPVKDVPC 573

Human   543 MFYIPQRPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQREGGWDAVMDWKD 607
            |||||||||||:|||.||:||||:.:||..|..|:.:|..||..|.|.||.||: .:|.|.||||
  Fly   574 MFYIPQRPYMSIGSLCDQIIYPDTREDMKRKHITENELRSILKMVSLEHIAQRD-SFDVVRDWKD 637

Human   608 VLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKGAGISLLSITHRPSLWKYHT 672
            :|||||||||.:||:|||:|:||||||||||||||||..|::.|||.||:||:|||||:||||||
  Fly   638 ILSGGEKQRMAIARLFYHRPRYALLDECTSAVSIDVESSIYEIAKGMGITLLTITHRPTLWKYHT 702

Human   673 HLLQFDGEGGWRFEQLDTAIRLTLSEEKQK 702
            |:|:|||.|.|:|.:::       |:|:||
  Fly   703 HILEFDGLGNWQFRKMN-------SDEEQK 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCD2	NP_005155.1	Interaction with PEX19. /evidence=ECO:0000269|PubMed:10777694	1..218		103/243 (42%)
		3a01203	74..685	CDD:273360	351/626 (56%)
Abcd1	NP_651906.1	3a01203	75..715	CDD:273360	355/653 (54%)