Protein Alignment ABCD2 and Abcd3

DIOPT Version :10

• Sequence 1: NP_005155.1
• Gene: ABCD2 / 225
• HGNCID: 66
• Length: 740
• Species: Homo sapiens
• Sequence 2: NP_608354.1
• Gene: Abcd3 / 32992
• FlyBaseID: FBgn0031069
• Length: 665
• Species: Drosophila melanogaster
• Alignment Length: 689
• Identity: 266/689 - (38%)
• Similarity: 391/689 - (56%)
• Gaps: 53/689 - (7%)

Human    17 SSAAKRAACLVAAAYALKTLYPIIGKRLKQSGHGKKKAAAYPAAENTEILHCTETICEKP----- 76
            |..|...:.:|..|.....|:.|...::.    .||:...|    ..:|.:   ||.||.
  Fly     6 SKLANNQSAIVGVAGMTAALWIIAYGKMS----NKKRKPGY----EDKIQY---TIAEKKDKKAG 59

Human    77 SPGVNADFFKQLLELRKILFPKLVTTETGWLCLHSVALISRTFLSIYVAGLDGKIVKSIVEKKPR 141
            ...||:.|||||.:|..||.|...:.|||.|.|.:.|||.|:...|::. .:..:|:|.:....|
  Fly    60 KAHVNSVFFKQLRQLLPILIPGFWSVETGLLFLVAAALIGRSVSDIWMI-QNATVVESTIIHMNR 123

Human   142 T-FIIKLIKWLMIAIPA-TFVNSAIRYLECKLALAFRTRLVDHAYETYFTNQTYYKVINMDGRLA 204
            | |...|:|:| .|:|| :.|.:.:::...:|.|.|||.|..|.|..|....||||:.|:|.|:|
  Fly   124 TKFKTALLKYL-TALPAISVVTNVLKWSLGELKLRFRTNLTHHLYSQYLNGYTYYKMSNLDNRIA 187

Human   205 NPDQSLTEDIMMFSQSVAHLYSNLTKPILDVMLTSYTLIQTATSRGASPIGPTLLAGLVVYATAK 269
            |.||.||.||..|.:|...||||::||:||:.:..|.|  |....|.:   |::|...:::|...
  Fly   188 NADQLLTTDIDKFCESATDLYSNISKPVLDIFIYVYRL--TVNLGGKT---PSILMLYLLFAGVF 247

Human   270 VLKACSPKFGKLVAEEAHRKGYLRYVHSRIIANVEEIAFYRGHKVEMKQLQKSYKALADQMNLIL 334
            :.:...|. |:|..||...:|..|||:||:|.|.||:|||:|:..|...|..||..|...:...|
  Fly   248 LTRLRRPT-GRLTVEEQKLEGEFRYVNSRLITNSEEVAFYQGNVREKLTLLASYSKLRSHLRKFL 311

Human   335 SKRLWYIMIEQFLMKYVWSSSGLIMVAIPIITAT-GFADGEDGQKQVMVSERTEAFTTARNLLAS 398
            ..|:...:|:..:.||..|..|...|:||..:.. ....||:.      .:|.:|:.|...:|..
  Fly   312 EFRVSMGIIDNIIGKYFASIVGFYAVSIPFFSENHPLLSGENS------GQRLQAYYTYGRMLVK 370

Human   399 GADAIERIMSSYKEVTELAGYTARVYNMFWVFDEVKRGIYKRTAVIQESESHSKNGAKVELPLSD 463
            .|:||.|::.:.:|::.|||:|||:..:..|..::.:|.|:||.|         ||..:   ..:
  Fly   371 LAEAIGRLVLAGREMSRLAGFTARMTELIKVLSDLNKGTYERTMV---------NGNNL---AQN 423

Human   464 TLAIKGKVIDVDHGIIC--------ENVPIITPAGEVVASRLNFKVEEGMHLLITGPNGCGKSSL 520
            .:.........:.||:|        |.||::||.|:|:...|:|:|:.|.::|:.||||||||||
  Fly   424 AVGSASSNFGPNKGIMCFEDNIIRFEKVPLVTPNGDVLLQELSFEVKSGTNVLVCGPNGCGKSSL 488

Human   521 FRILSGLWPVYEGVLYKPPPQHMFYIPQRPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILH 585
            ||||..|||.:.|.:.||....:||:||||||:||:||||:|||.:.|||...|::|:||...|.
  Fly   489 FRILGELWPTWGGKVTKPSRGKLFYVPQRPYMTLGTLRDQIIYPHTRDDMRRLGHSDEDLMHYLD 553

Human   586 NVHLYHIVQREGGWDAVMDWKDVLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQA 650
            .|.|.::.|||.|.|::.||.||||||||||:.|||:|||||::|:|||||||||:|||||::..
  Fly   554 IVQLTYLEQRENGLDSIEDWIDVLSGGEKQRIAMARLFYHKPQFAILDECTSAVSVDVEGKMYSY 618

Human   651 AKGAGISLLSITHRPSLWKYHTHLLQFDGEGGWRFEQLD 689
            .:..||:|.:::||.|||.:|.:.|||||.|.:.|..:|
  Fly   619 CREVGITLFTVSHRKSLWAHHDYYLQFDGRGSYEFATID 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCD2	NP_005155.1	Interaction with PEX19. /evidence=ECO:0000269|PubMed:10777694	1..218		71/207 (34%)
		3a01203	74..685	CDD:273360	252/626 (40%)
Abcd3	NP_608354.1	3a01203	3..653	CDD:273360	264/683 (39%)