Protein Alignment FGB and CG9593

DIOPT Version :10

• Sequence 1: NP_005132.2
• Gene: FGB / 2244
• HGNCID: 3662
• Length: 491
• Species: Homo sapiens
• Sequence 2: NP_650493.2
• Gene: CG9593 / 41912
• FlyBaseID: FBgn0038365
• Length: 382
• Species: Drosophila melanogaster
• Alignment Length: 518
• Identity: 134/518 - (25%)
• Similarity: 191/518 - (36%)
• Gaps: 189/518 - (36%)

Human    15 MKHLLLLLL---CVFLVKSQGVN---DNEEGFFS-----------------ARG-----HRPLDK 51
            ||..||.||   ||||..:..:|   :::.||.|                 .||     ||.|.|
  Fly     2 MKFSLLFLLAWSCVFLGSTGSLNRIGNSDIGFKSLEELVLIRKTLAAQALKLRGLEINLHRVLSK 66

Human    52 KREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEAL 116
            ....|.::...|     |.|.::                       .|| |.||......|.|.|
  Fly    67 VVLLADAVVQVP-----GRYSSK-----------------------EDP-LAVLSERLNLLLERL 102

Human   117 LQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQL 181
            .|:|| |..::.||......|.|..|.|   ..|.|:|.::     ||...|.....::.:.|:|
  Fly   103 NQEER-ISTNLLELKEWSTKVCQEPSPS---QTLPKELTEE-----KDEPKVDFYQPAKSDCHEL 158

Human   182 YIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIR 246
              ||.|..:     .|.|.::.. |:::|:   |:
  Fly   159 --DEGVRVD-----GVYRFLVPE-RNEVQR---DL------------------------------ 182

Human   247 KGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVD----FGRKWDPYKQGFGNVA 307
                               |..||...|:...|||||:| .||.|    |.|.||.|:.||||
  Fly   183 -------------------YERYCAFATDGPAWTVIQSR-GGSFDPHENFNRSWDEYRAGFGN-- 225

Human   308 TNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEME------DWKGDKVKAHYGGFTVQNEAN 366
                      |..::|.||:...::......||.||::      ||      |.|..|.:.:|:.
  Fly   226 ----------LSRDFWFGNEFAHKILYRDDHELRIELQEAGEPLDW------AEYPLFWLDSESY 274

Human   367 KYQISV-NKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGG 430
            .||:|| .::||:..:||..              ||.|.||||||..:...::|  ..|.::.||
  Fly   275 NYQLSVAGEFRGSLPDALEQ--------------HNRMDFSTYDRRRNHAKSAD--STCGEDYGG 323

Human   431 GWWYNRCHAANPNGRYYWGGQYTWDMAKHG----TDDGVVWMNWKGSWYSMRKMSMKIRPFFP 489
            |||::||...|.||             :||    ....::||||:......:...|.|||..|
  Fly   324 GWWFDRCTQCNLNG-------------EHGVHQRASPAIIWMNWRTGTDKPKSSRMMIRPVNP 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGB	NP_005132.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	44..75		10/35 (29%)
		Beta-chain polymerization, binding distal domain of another fibrin	45..47		1/6 (17%)
		Fib_alpha	91..234	CDD:462570	34/142 (24%)
		Fibrinogen_C	237..486	CDD:395095	73/263 (28%)
CG9593	NP_650493.2	FReD	150..371	CDD:238040	84/328 (26%)