Protein Alignment FGA and sca

DIOPT Version :10

• Sequence 1: NP_000499.1
• Gene: FGA / 2243
• HGNCID: 3661
• Length: 866
• Species: Homo sapiens
• Sequence 2: NP_476710.2
• Gene: sca / 36411
• FlyBaseID: FBgn0003326
• Length: 799
• Species: Drosophila melanogaster
• Alignment Length: 915
• Identity: 199/915 - (21%)
• Similarity: 332/915 - (36%)
• Gaps: 271/915 - (29%)

Human     6 IVCLVLSVVGTAWTADSGEGDFLAE--GGGVRGPRVVERHQSAC---KDSDWP--------FCSD 57
            ::.:||..:..|:.:.:..|..:..  ...:|..:||...:...   ::::.|        |..|
  Fly    36 LLAVVLLQISVAFVSGAASGGVVLSDVNNMLRDAKVVTSEKPVVHSKQETEAPESSVELLRFVDD 100

Human    58 EDWNYKCPSGCRMKG-------LIDEVNQDFTNRINKL---KNSLFEYQKNN-KDSHSLTTNIME 111
            ::.:....|..|..|       :.|:|.. .|.::|.|   :...:|..::| :.|..||||.
  Fly   101 DEDSEDISSIERQDGRTMESKKMADQVRL-LTKQLNALMLRRREDYEMLEHNLRKSLRLTTNA-- 162

Human   112 ILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIE------------KVQHIQLLQKNVRAQLV 164
                            |.|..|:||.:..|:.::..            .|:.:|.....:|.|||
  Fly   163 ----------------NSVDADMRSELNQLREELAALRSSQSGNKERLTVEWLQQTISEIRKQLV 211

Human   165 DMKRLEVDI--DIKIRSCRGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDRQHLPLIKMK 227
            |::|...::  |::.||         :...||.......:||:    .||...|:||....:.::
  Fly   212 DLQRTASNVAQDVQQRS---------STFEDLATIRSDYQQLK----LDLAAQRERQQQTEVYVQ 263

Human   228 PVPDLVPGNFKSQLQKVPPEWKALTDMPQMRMELERPGGNEITRGGSTSYGTGSETESPRNPSSA 292
            .:.:       ..||:......||..:.|.
  Fly   264 ELRE-------EMLQQEQDFQHALVKLQQR----------------------------------- 286

Human   293 GSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSWNSGSSGTG--STGNQNPGSPRPG 355
                          .|..|||           :|....:||..:....||  :|.:......|..
  Fly   287 --------------TRKDGSS-----------ASVEEESGSQEANQEQTGLETTADHKRRHCRFQ 326

Human   356 STGTWNPGSSER-------GSAGHWTSESSVSGSTGQWHSESGSFRPDSPGSGNARPNNPDWGTF 413
            |........::|       |...|...|...|....|....:.:|
  Fly   327 SEQIHQLQLAQRNLRRQVNGLRFHHIDERVRSIEVEQHRIANANF-------------------- 371

Human   414 EEVSGNVSPGTRREYHTEKLVTSKGDKELRTGKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEV 478
             .:|..::  :..:.||..|...:..:.|:|..:|    |....|...||.       ...:.::
  Fly   372 -NLSSQIA--SLDKLHTSMLELLEDVEGLQTKMDK----SIPELRHEISKL-------EFANAQI 422

Human   479 TKE-VVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRHPDEAAFFDTASTGKTFPGFFSPMLGEFVS 542
            |.| .:..|:|::...::....:| :..|...|......:|..|...|.       ...|...|:
  Fly   423 TSEQSLIREEGTNAARSLQAMAVS-VSVLQEEREGMRKLSANVDQLRTN-------VDRLQSLVN 479

Human   543 ETESRGSESGIFTNTKESSSHHPGI-AEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADE 606
            : |.:...:.:  |......||..: |:.|                   :.||..:|   .:|:.
  Fly   480 D-EMKNKLTHL--NKPHKRPHHQNVQAQMP-------------------QDDSPIDS---VLAET 519

Human   607 AGSEADHEGTH----STKRGHAKSRPVRDCDDVLQTHPSGTQS-GIFNIKLPGSSKIFSVYCDQE 666
            ..||.::..|.    ..|..|       ||.:|   |   ||: |:..|...|.......:|..:
  Fly   520 LVSELENVETQYEAIINKLPH-------DCSEV---H---TQTDGLHLIAPAGQRHPLMTHCTAD 571

Human   667 TSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNDEGEGEFWLGNDYLHLLT-QRGSVLRVELED 730
                ||..:|:|.|||.:|||:|.||.:|||:..    ||||:||:.||.|| ...|.|:|:::|
  Fly   572 ----GWTTVQRRFDGSADFNRSWADYAQGFGAPG----GEFWIGNEQLHHLTLDNCSRLQVQMQD 628

Human   731 WAGNEAYAEY-HFRVGSEAEGYALQVSSYEGTAGDALIEGSVEEGAEYTSHNNMQFSTFDRDADQ 794
            ...|...||| .|.:.|.|:||.|.::.|.|.|.|||   :.::|        ||||..|.|.|.
  Fly   629 IYDNVWVAEYKRFYISSRADGYRLHIAEYSGNASDAL---NYQQG--------MQFSAIDDDRDI 682

Human   795 WEENCAEVYGGGWWYNNCQAANLNGIYYPGGS-YDPRNNSPYEIENGVVWVSFRGADYSLRAVRM 858
            .:.:||..|.||||:::||.|||||.|..|.: :|...|.         |:       ::::.||
  Fly   683 SQTHCAANYEGGWWFSHCQHANLNGRYNLGLTWFDAARNE---------WI-------AVKSSRM 731

Human   859 KIRPL 863
            .::.|
  Fly   732 LVKRL 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGA	NP_000499.1	Alpha-chain polymerization, binding distal domain of another fibrin gamma chain	36..38		0/1 (0%)
		Fib_alpha	49..191	CDD:462570	35/174 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	262..460		28/206 (14%)
		Fibrinogen_aC	445..509	CDD:432370	11/64 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	543..638		18/99 (18%)
		FReD	630..863	CDD:238040	85/236 (36%)
sca	NP_476710.2	PRK03918	134..>485	CDD:235175	83/491 (17%)
		FBG	538..736	CDD:214548	86/245 (35%)