Protein Alignment FGA and CG1889

DIOPT Version :10

• Sequence 1: NP_000499.1
• Gene: FGA / 2243
• HGNCID: 3661
• Length: 866
• Species: Homo sapiens
• Sequence 2: NP_727376.2
• Gene: CG1889 / 31928
• FlyBaseID: FBgn0030164
• Length: 338
• Species: Drosophila melanogaster
• Alignment Length: 246
• Identity: 88/246 - (35%)
• Similarity: 120/246 - (48%)
• Gaps: 32/246 - (13%)

Human   622 GHAKSRPVRDCDDVLQTHPSGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFN 686
            |.|.:.|:...:.:.|.|      |:..|:...:.:.|.|:|||:...|||.::..|.|||.:||
  Fly   116 GGAAAVPITPANCLKQQH------GVVRIRPRSNVEPFFVFCDQKVRNGGWTMVVNRYDGSEDFN 174

Human   687 RTWQDYKRGFGSLNDEGEGEFWLGNDYLHLLTQRGSV-LRVELEDWAGNEAYAEY-HFRVGSEAE 749
            |.|.|||.|||.|..    ||::|.|.||.:|...:. |.|:|::......||.| ||.:|||:|
  Fly   175 RKWADYKIGFGPLTT----EFFIGLDKLHQITSSDNYELLVQLQNRKQELRYALYDHFSIGSESE 235

Human   750 GYALQV-SSYEGTAGDALIEGSVEEGAEYTSHNNMQFSTFDRDADQWEENCAEVYGGGWWY-NNC 812
            .|.|.| ..|.|.|.|||           ..|...:|||.||..|:.|:|||....|.:|| .:|
  Fly   236 QYRLNVLGDYHGDAADAL-----------RDHTGKKFSTHDRVNDENEQNCAAQQSGAFWYGGSC 289

Human   813 QAANLNGIYYPGGSYDPRNNSPYEIENGVVWVSF-RGADYSLRAVRMKIRP 862
            ...|      |.|.|........:...|::|..| .|...||:.|||.:||
  Fly   290 NLTN------PFGLYQRLLERDVDGFKGILWRGFLNGPKGSLKIVRMMVRP 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGA	NP_000499.1	Alpha-chain polymerization, binding distal domain of another fibrin gamma chain	36..38
		Fib_alpha	49..191	CDD:462570
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	262..460
		Fibrinogen_aC	445..509	CDD:432370
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	543..638		3/15 (20%)
		FReD	630..863	CDD:238040	85/238 (36%)
CG1889	NP_727376.2	FReD	123..335	CDD:238040	85/239 (36%)