Protein Alignment FGA and CG30281

DIOPT Version :10

• Sequence 1: NP_000499.1
• Gene: FGA / 2243
• HGNCID: 3661
• Length: 866
• Species: Homo sapiens
• Sequence 2: NP_726164.1
• Gene: CG30281 / 246525
• FlyBaseID: FBgn0050281
• Length: 291
• Species: Drosophila melanogaster
• Alignment Length: 292
• Identity: 104/292 - (35%)
• Similarity: 140/292 - (47%)
• Gaps: 65/292 - (22%)

Human   589 YNRGDSTFES---------KSYKMADEAGSEADHEGTHSTKRGHAKSRPVRDCDDVLQTHPSG-- 642
            |.:.:|...|         :|||...|      ..|:|.|                  .:||.
  Fly    29 YKKAESMVSSLKIRLEELKQSYKEITE------ERGSHET------------------INPSSCL 69

Human   643 ----TQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNDEG 703
                ..:||..|::||... |.||||...:..||.:||:|.|||.||.|.|::|.:|||.|:
  Fly    70 AAGINSNGIHVIEVPGLEP-FPVYCDTRLAGSGWTVIQRRQDGSENFYRCWEEYSQGFGELS--- 130

Human   704 EGEFWLGNDYLHLLTQRGSV-LRVELEDWAGNEAYAEYH-FRVGSEAEGYALQV-SSYEGTAGDA 765
             |||::|.:.||.||..... |.|.:||:.|....|.|. |.:|:.:..|||.| ..|.|.|||:
  Fly   131 -GEFFMGLEKLHFLTTAEPYELFVYMEDFNGVVHDARYEDFAIGNASASYALSVLGKYSGDAGDS 194

Human   766 LIEGSVEEGAEYTSHNNMQFSTFDRDADQWEENCAEVYGGGWWYNNCQAANLNGIYYPGGSYDPR 830
            |         .|  |..|.|||||.  |.....||.:|.|.|||:.||.:||||.|..||.::|:
  Fly   195 L---------RY--HKGMPFSTFDH--DDTGHGCARIYVGAWWYDQCQRSNLNGQYLEGGRFEPK 246

Human   831 NNSPYEIENGVVWVSFRGADYSLRAVRMKIRP 862
            .:.     .|:.|:|:||.||..:.|:|.|||
  Fly   247 MSG-----RGITWMSWRGYDYGYKFVQMMIRP 273

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGA	NP_000499.1	Alpha-chain polymerization, binding distal domain of another fibrin gamma chain	36..38
		Fib_alpha	49..191	CDD:462570
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	262..460
		Fibrinogen_aC	445..509	CDD:432370
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	543..638		10/57 (18%)
		FReD	630..863	CDD:238040	94/242 (39%)
CG30281	NP_726164.1	FReD	63..274	CDD:238040	94/234 (40%)